Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy

Lauris Smits; I. Ozolanta; V. Ozolins; A. Lacis; V. Kasyanov

doi:10.1007/978-3-540-69367-3_21

Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy

Lauris Smits, I. Ozolanta, V. Ozolins, A. Lacis, V. Kasyanov

Rīga Stradiņš University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Ventricular septal defect (VSD) is the most common congenital heart disease (15-20%). The traditional treatment is surgical repair - VSD closure using the autologous pericard or synthetic material - polytetrafluorethylene. The aim of this research is to investigate the biomechanical properties of two synthetic materials and to biomechanicaly compare the properties of the PTFE (polytertaflourethylene) material patches - GORE TEX and BARD in vitro studies the elastic modulus E (MPa), ultimate stress ε (%) and ultimate strain σ (MPa) of both. We suspect that knitted material (BARD) would be more appropriate for myocardial tissues. Two types of PTFE patches were investigated: GORE TEX Cardiovascular Patch (GRTX), and BARD Edwards Outflow Tract Fabric knitted PTFE Patch (BARD). Every type of patch was divided into 3 subgroups: I subgroup - fresh material, II subgroup - 1 month exposed, III subgroup - exposed for 3months in sterile saline 0,9% at 37°C. The testing data were recorded with software (Testexpert 11.02, Zwick-Roell). For non-treated GRTX material σ_max decreased after three months treatment from 8.62±0.21 MPa to 7.36±1.45 MPa(p<0.05). ε_max increased from 16.52±1.76% to 17.26±3.54%(p=0.05). Modulus of elasticity (E) of GRTX material decrease from 84.46±11.8 MPa (for non-treated) to 59.65±5.03 MPa (p<0.05).There are statistical differences between II and III subgroup of E: 79.24±16.82 MPa and 59.65±5.03 MPa(p<0.019). σ_max for non treated BARD material decreased after three months from 11,19 ± 1,03 MPa to 8,55 ± 0,62 MPa(p<0.05). ε_max increased from 48.38±2.32% to 69.55±3.67%(p<0.05) after. E modulus decreased from 15.12±0.75 MPa to 8.12±0.48 MPa(p<0.05). After three months of treatment by saline the ε_max of BARD material is 48.38±2.32%, but ε_max of GRTX is 17.26±3.54% (p<0.05).Results show that BARD patch is not so stiff as GRTX patch, and is more suitable for the VSD closure in the first year life of children.

Original language	English
Title of host publication	14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008
Publisher	Springer Verlag
Pages	76-79
Number of pages	4
Volume	20
ISBN (Print)	9783540693666
DOIs	https://doi.org/10.1007/978-3-540-69367-3_21
Publication status	Published - 2008
Event	14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics - Riga, Latvia Duration: 16 Jun 2008 → 20 Jun 2008 Conference number: 14 https://www.worldcat.org/title/14th-nordic-baltic-conference-on-biomedical-engineering-and-medical-physics-nbc-2008-16-20-june-2008-riga-latvia/oclc/929007847

Publication series

Name	IFMBE Proceedings
Volume	20 IFMBE
ISSN (Print)	1680-0737

Conference

Conference	14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics
Abbreviated title	NBC 2008
Country/Territory	Latvia
City	Riga
Period	16/06/08 → 20/06/08
Internet address	https://www.worldcat.org/title/14th-nordic-baltic-conference-on-biomedical-engineering-and-medical-physics-nbc-2008-16-20-june-2008-riga-latvia/oclc/929007847

Keywords*

biomechanical properties
infant
polytetrafluorethylene
ventricular septal defect

Field of Science*

2.5 Materials engineering
2.6 Medical engineering

Publication Type*

3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

Access to Document

10.1007/978-3-540-69367-3_21

Cite this

Smits, L., Ozolanta, I., Ozolins, V., Lacis, A., & Kasyanov, V. (2008). Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy. In 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008 (Vol. 20, pp. 76-79). (IFMBE Proceedings; Vol. 20 IFMBE). Springer Verlag. https://doi.org/10.1007/978-3-540-69367-3_21

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title = "Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy",

abstract = "Ventricular septal defect (VSD) is the most common congenital heart disease (15-20%). The traditional treatment is surgical repair - VSD closure using the autologous pericard or synthetic material - polytetrafluorethylene. The aim of this research is to investigate the biomechanical properties of two synthetic materials and to biomechanicaly compare the properties of the PTFE (polytertaflourethylene) material patches - GORE TEX and BARD in vitro studies the elastic modulus E (MPa), ultimate stress ε (%) and ultimate strain σ (MPa) of both. We suspect that knitted material (BARD) would be more appropriate for myocardial tissues. Two types of PTFE patches were investigated: GORE TEX Cardiovascular Patch (GRTX), and BARD Edwards Outflow Tract Fabric knitted PTFE Patch (BARD). Every type of patch was divided into 3 subgroups: I subgroup - fresh material, II subgroup - 1 month exposed, III subgroup - exposed for 3months in sterile saline 0,9% at 37°C. The testing data were recorded with software (Testexpert 11.02, Zwick-Roell). For non-treated GRTX material σmax decreased after three months treatment from 8.62±0.21 MPa to 7.36±1.45 MPa(p<0.05). εmax increased from 16.52±1.76% to 17.26±3.54%(p=0.05). Modulus of elasticity (E) of GRTX material decrease from 84.46±11.8 MPa (for non-treated) to 59.65±5.03 MPa (p<0.05).There are statistical differences between II and III subgroup of E: 79.24±16.82 MPa and 59.65±5.03 MPa(p<0.019). σmax for non treated BARD material decreased after three months from 11,19 ± 1,03 MPa to 8,55 ± 0,62 MPa(p<0.05). εmax increased from 48.38±2.32% to 69.55±3.67%(p<0.05) after. E modulus decreased from 15.12±0.75 MPa to 8.12±0.48 MPa(p<0.05). After three months of treatment by saline the εmax of BARD material is 48.38±2.32%, but εmax of GRTX is 17.26±3.54% (p<0.05).Results show that BARD patch is not so stiff as GRTX patch, and is more suitable for the VSD closure in the first year life of children.",

keywords = "biomechanical properties, infant, polytetrafluorethylene, ventricular septal defect",

author = "Lauris Smits and I. Ozolanta and V. Ozolins and A. Lacis and V. Kasyanov",

year = "2008",

doi = "10.1007/978-3-540-69367-3_21",

language = "English",

isbn = "9783540693666",

volume = "20",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

pages = "76--79",

booktitle = "14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008",

address = "Germany",

note = "14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008 ; Conference date: 16-06-2008 Through 20-06-2008",

url = "https://www.worldcat.org/title/14th-nordic-baltic-conference-on-biomedical-engineering-and-medical-physics-nbc-2008-16-20-june-2008-riga-latvia/oclc/929007847",

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Smits, L, Ozolanta, I, Ozolins, V, Lacis, A & Kasyanov, V 2008, Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy. in 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008. vol. 20, IFMBE Proceedings, vol. 20 IFMBE, Springer Verlag, pp. 76-79, 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, Riga, Latvia, 16/06/08. https://doi.org/10.1007/978-3-540-69367-3_21

Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy. / Smits, Lauris; Ozolanta, I.; Ozolins, V. et al.
14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008. Vol. 20 Springer Verlag, 2008. p. 76-79 (IFMBE Proceedings; Vol. 20 IFMBE).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy

AU - Smits, Lauris

AU - Ozolanta, I.

AU - Ozolins, V.

AU - Lacis, A.

AU - Kasyanov, V.

N1 - Conference code: 14

PY - 2008

Y1 - 2008

N2 - Ventricular septal defect (VSD) is the most common congenital heart disease (15-20%). The traditional treatment is surgical repair - VSD closure using the autologous pericard or synthetic material - polytetrafluorethylene. The aim of this research is to investigate the biomechanical properties of two synthetic materials and to biomechanicaly compare the properties of the PTFE (polytertaflourethylene) material patches - GORE TEX and BARD in vitro studies the elastic modulus E (MPa), ultimate stress ε (%) and ultimate strain σ (MPa) of both. We suspect that knitted material (BARD) would be more appropriate for myocardial tissues. Two types of PTFE patches were investigated: GORE TEX Cardiovascular Patch (GRTX), and BARD Edwards Outflow Tract Fabric knitted PTFE Patch (BARD). Every type of patch was divided into 3 subgroups: I subgroup - fresh material, II subgroup - 1 month exposed, III subgroup - exposed for 3months in sterile saline 0,9% at 37°C. The testing data were recorded with software (Testexpert 11.02, Zwick-Roell). For non-treated GRTX material σmax decreased after three months treatment from 8.62±0.21 MPa to 7.36±1.45 MPa(p<0.05). εmax increased from 16.52±1.76% to 17.26±3.54%(p=0.05). Modulus of elasticity (E) of GRTX material decrease from 84.46±11.8 MPa (for non-treated) to 59.65±5.03 MPa (p<0.05).There are statistical differences between II and III subgroup of E: 79.24±16.82 MPa and 59.65±5.03 MPa(p<0.019). σmax for non treated BARD material decreased after three months from 11,19 ± 1,03 MPa to 8,55 ± 0,62 MPa(p<0.05). εmax increased from 48.38±2.32% to 69.55±3.67%(p<0.05) after. E modulus decreased from 15.12±0.75 MPa to 8.12±0.48 MPa(p<0.05). After three months of treatment by saline the εmax of BARD material is 48.38±2.32%, but εmax of GRTX is 17.26±3.54% (p<0.05).Results show that BARD patch is not so stiff as GRTX patch, and is more suitable for the VSD closure in the first year life of children.

AB - Ventricular septal defect (VSD) is the most common congenital heart disease (15-20%). The traditional treatment is surgical repair - VSD closure using the autologous pericard or synthetic material - polytetrafluorethylene. The aim of this research is to investigate the biomechanical properties of two synthetic materials and to biomechanicaly compare the properties of the PTFE (polytertaflourethylene) material patches - GORE TEX and BARD in vitro studies the elastic modulus E (MPa), ultimate stress ε (%) and ultimate strain σ (MPa) of both. We suspect that knitted material (BARD) would be more appropriate for myocardial tissues. Two types of PTFE patches were investigated: GORE TEX Cardiovascular Patch (GRTX), and BARD Edwards Outflow Tract Fabric knitted PTFE Patch (BARD). Every type of patch was divided into 3 subgroups: I subgroup - fresh material, II subgroup - 1 month exposed, III subgroup - exposed for 3months in sterile saline 0,9% at 37°C. The testing data were recorded with software (Testexpert 11.02, Zwick-Roell). For non-treated GRTX material σmax decreased after three months treatment from 8.62±0.21 MPa to 7.36±1.45 MPa(p<0.05). εmax increased from 16.52±1.76% to 17.26±3.54%(p=0.05). Modulus of elasticity (E) of GRTX material decrease from 84.46±11.8 MPa (for non-treated) to 59.65±5.03 MPa (p<0.05).There are statistical differences between II and III subgroup of E: 79.24±16.82 MPa and 59.65±5.03 MPa(p<0.019). σmax for non treated BARD material decreased after three months from 11,19 ± 1,03 MPa to 8,55 ± 0,62 MPa(p<0.05). εmax increased from 48.38±2.32% to 69.55±3.67%(p<0.05) after. E modulus decreased from 15.12±0.75 MPa to 8.12±0.48 MPa(p<0.05). After three months of treatment by saline the εmax of BARD material is 48.38±2.32%, but εmax of GRTX is 17.26±3.54% (p<0.05).Results show that BARD patch is not so stiff as GRTX patch, and is more suitable for the VSD closure in the first year life of children.

KW - biomechanical properties

KW - infant

KW - polytetrafluorethylene

KW - ventricular septal defect

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U2 - 10.1007/978-3-540-69367-3_21

DO - 10.1007/978-3-540-69367-3_21

M3 - Conference contribution

AN - SCOPUS:78049381486

SN - 9783540693666

VL - 20

T3 - IFMBE Proceedings

SP - 76

EP - 79

BT - 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008

PB - Springer Verlag

T2 - 14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics

Y2 - 16 June 2008 through 20 June 2008

ER -

Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy

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Keywords*

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