Biomechanical properties of two synthetic biomaterials for ventricular septal defect closure in infancy

Lauris Smits, I. Ozolanta, V. Ozolins, A. Lacis, V. Kasyanov

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)


Ventricular septal defect (VSD) is the most common congenital heart disease (15-20%). The traditional treatment is surgical repair - VSD closure using the autologous pericard or synthetic material - polytetrafluorethylene. The aim of this research is to investigate the biomechanical properties of two synthetic materials and to biomechanicaly compare the properties of the PTFE (polytertaflourethylene) material patches - GORE TEX and BARD in vitro studies the elastic modulus E (MPa), ultimate stress ε (%) and ultimate strain σ (MPa) of both. We suspect that knitted material (BARD) would be more appropriate for myocardial tissues. Two types of PTFE patches were investigated: GORE TEX Cardiovascular Patch (GRTX), and BARD Edwards Outflow Tract Fabric knitted PTFE Patch (BARD). Every type of patch was divided into 3 subgroups: I subgroup - fresh material, II subgroup - 1 month exposed, III subgroup - exposed for 3months in sterile saline 0,9% at 37°C. The testing data were recorded with software (Testexpert 11.02, Zwick-Roell). For non-treated GRTX material σmax decreased after three months treatment from 8.62±0.21 MPa to 7.36±1.45 MPa(p<0.05). εmax increased from 16.52±1.76% to 17.26±3.54%(p=0.05). Modulus of elasticity (E) of GRTX material decrease from 84.46±11.8 MPa (for non-treated) to 59.65±5.03 MPa (p<0.05).There are statistical differences between II and III subgroup of E: 79.24±16.82 MPa and 59.65±5.03 MPa(p<0.019). σmax for non treated BARD material decreased after three months from 11,19 ± 1,03 MPa to 8,55 ± 0,62 MPa(p<0.05). εmax increased from 48.38±2.32% to 69.55±3.67%(p<0.05) after. E modulus decreased from 15.12±0.75 MPa to 8.12±0.48 MPa(p<0.05). After three months of treatment by saline the εmax of BARD material is 48.38±2.32%, but εmax of GRTX is 17.26±3.54% (p<0.05).Results show that BARD patch is not so stiff as GRTX patch, and is more suitable for the VSD closure in the first year life of children.

Original languageEnglish
Title of host publication14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2008
PublisherSpringer Verlag
Number of pages4
ISBN (Print)9783540693666
Publication statusPublished - 2008
Event14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics - Riga, Latvia
Duration: 16 Jun 200820 Jun 2008
Conference number: 14

Publication series

NameIFMBE Proceedings
Volume20 IFMBE
ISSN (Print)1680-0737


Conference14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics
Abbreviated titleNBC 2008
Internet address


  • biomechanical properties
  • infant
  • polytetrafluorethylene
  • ventricular septal defect

Field of Science*

  • 2.5 Materials engineering
  • 2.6 Medical engineering

Publication Type*

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database


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