Body Muscle Mass Metabolic Data Analysis in Association with Crohn's Disease Activity

Polina Zaaizko (Coresponding Author), Monta Urbane, Tereze Hermine Roshofa, Viktorija Mokricka, Laila Meija, Edgars Bodnieks, Aldis Pukitis

Research output: Contribution to journalArticlepeer-review


Malnutrition is a common complication of Crohn's disease (CD) patients and it is correlated with alterations of the body composition and disease activity. Our prospective pilot study included hospitalised CD patients, age ≥ 18 years. Patients were assessed using the Nutritional Risk Score (NRS2002), the Malnutrition Universal Screening Tool (MUST), and body bioelectrical impedance analysis. Twenty-three hospitalised patients (median age 36.5, interquartile range (IQR): 28.5-51.5 years) were enrolled; the median CD activity index was 128 (IQR = 6.0-207.0). The study group comprised 48% (n = 11) patients with low CD activity and 52% (n = 12) with high disease activity. According to NRS2002 and MUST, 70% (n = 16) CD patients had malnutrition risk and were in need of nutritional support. The median BMI was lower for the CD group (21.10 [IQR = 19.2-23.3]) than for the control group (23.4 [IQR = 21.5-25.8]) (p = 0.014). In terms of deviation from standard weight, 39% (n = 9) of CD patients showed reduced % body fat. Reduced muscle mass was observed in 48% (n = 11) of CD patients. CD patients with high disease activity had a noticeably increased risk of malnutrition. Identification of the reduction in soft lean muscle mass in CD patients can be used as an anticipatory indicator of disease activity.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Issue number1
Publication statusPublished - 1 Feb 2022


  • Crohn's disease activity index
  • inflammatory bowel disease
  • malnutrition
  • screening tools

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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