BREAST CANCER AS SECOND MALIGNANCY FOR MOTHER AND DAUGHTER WITHOUT GENETIC FINDING: A CASE REPORT

Santa Strapcāne, Vija Siliņa (Scientific Advisor)

Research output: Contribution to conferenceAbstractpeer-review

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Abstract

Introduction. Around half of breast cancers develop without a known cause, and yet it is important to have early diagnosis. General practitioner should be able to recognize situations and when to interfere, although is not always easy to correlate events as 10% of cases are hereditary and environment factors could be responsible for one third.
Case description. 73-year-old patient receiving polycythemia vera treatment for 6 years presented with painless 2cm lump in right breast. Mammography (R5) and consecutive biopsy showed ductal invasive breast cancer (pT1cN0M0G2R0). Besides, patient has also undergone basal cell carcinoma treatment in last years. Patient has a significant occupational history – 30 years of ionizing radiation exposure. The patient`s daughter (46-years-old), having breast cancer in first-degree female relative, but no complaints, was referred to mammography for early screening. Daughter also has anamnesis of retinoblastoma (diagnosed at 3-yearsold, surgically eradicated and treated with radiotherapy). Mammography showed calcium deposits in one breast (R3). After biopsy high grade ductal carcinoma in situ (pTisN0M0R0) was diagnosed. Considering family and individual anamnesis of having 2 malignancies, genetic testing for the available oncology genes was performed, but nothing affirmative was found.
Summary. This case presents interaction of diverse causes and risk factors. Exposure to ionizing radiation is well-established environmental cause of breast cancer. Malignancies as polycythemia vera and retinoblastoma might have higher incidence for breast cancer later on. Most importantly having first-degree relative with breast cancer approximately doubles the risk of breast cancer.
Conclusions. Even without genetic correlation, general practitioner should consider family and individual history of malignancies that could increase the risk of breast cancer as important evidence in the consideration of early check-up, in addition to long-term risk factors.

Keywords*

  • Breast malignancies
  • History of radiation exposure

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)

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