TY - JOUR
T1 - Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement
AU - Danilevicius, Paulius
AU - Rezende, Rodrigo A.
AU - Pereira, Frederico D.A.S.
AU - Selimis, Alexandros
AU - Kasyanov, Vladimir
AU - Noritomi, Pedro Y.
AU - da Silva, Jorge V.L.
AU - Chatzinikolaidou, Maria
AU - Farsari, Maria
AU - Mironov, Vladimir
N1 - Publisher Copyright:
© 2015 American Vacuum Society.
PY - 2015/6/23
Y1 - 2015/6/23
N2 - The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a Microsquisher®. They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.
AB - The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a Microsquisher®. They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.
UR - https://www.scopus.com/pages/publications/84946204749
U2 - 10.1116/1.4922646
DO - 10.1116/1.4922646
M3 - Article
C2 - 26104190
AN - SCOPUS:84946204749
SN - 1934-8630
VL - 10
JO - Biointerphases
JF - Biointerphases
IS - 2
M1 - 021011
ER -