CAGA ASSOCIATION WITH GASTRIC CANCER DEVELOPMENT RISK

Liene Vanaga; Ilva Daugule; Georgijs Moisejevs; Dace Rudzite; Sergey Krotov; Dainius Janciauskas; Inta Liepniece-Karele; Sergejs Isajevs; Armands Sivins; Ilze Kikuste; Guntis Ancans; Konrads Funka; Ieva Lasina; Ivars Tolmanis; Aigars Vanags; Marcis Leja

Abstract

Introduction: Helicobacter pylori (HP) infection is known risk factor for development gastric cancer. One of the most studied virulence factors is cytotoxin associated gene (cagA). The aim of this study was to investigate whether CagA seropositivity is associated with risk of development gastric cancer. Methods: Gastric cancer group included patients with histolopathologicaly proven disease (n = 219, median of age – 66, males/females 92/127) and control group was represented by dyspeptic patients (n = 191, median of age – 56, males/females 67/124) having no evidence of gastric mucosa atrophy, evaluated according to Operative Link for Gastritis Assessment (OLGA) with score 0-I. HP seropositivity was determined using anti-HP IgG (Biohit, Finland) and antiCagA IgG, IgM and IgA (Vector BEST, Russia). Statistical test used – v2 . Results: Rate of HP seropositivity among gastric cancer patients was significantly highar compared to control group (77.2 % vs 64.4%, p = 0.03). Compared to control group, gastric cancer patients had significantly higher rate of anti-CagA seropositivity (44% vs 58.9%, OR = 1.8, CI 95% = 1.23–2.70, p = 0.002). Conclusions: Having HP infection positive to CagA virulence factor significantly increases risk of development of gastric cancer. However gastric cancer development process is very complex and interaction of host and HP factors should be studied precisely. Acknowledgements: Study was supported by ERDF project Nr.2010/0302/ 2DP/2.1.1.1.0/10/APIA/VIAA/158.

Original language	English
Article number	P18.12
Pages (from-to)	152-153
Journal	Helicobacter
Volume	18
Issue number	Suppl.1
Publication status	Published - Sept 2013
Event	XXVIth International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer - Madrid, Spain Duration: 12 Sept 2013 → 14 Sept 2013 Conference number: 26 https://www.nutricion.ucr.ac.cr/index.php/es/proyectos/publicaciones/376-geographic-origin-of-helicobacter-pylori-isolated-from-costa-rican-patients-european-helicobacter-study-group-xxvith-international-workshop-on-helicobacter-and-related-bacteria-in-chronic-digestive-inflammation-and-gastric-cancer

Field of Science*

3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1111/hel.12079

Cite this

@article{a9ddf37c1aab487a867c50c9af37ec9a,

title = "CAGA ASSOCIATION WITH GASTRIC CANCER DEVELOPMENT RISK",

abstract = "Introduction: Helicobacter pylori (HP) infection is known risk factor for development gastric cancer. One of the most studied virulence factors is cytotoxin associated gene (cagA). The aim of this study was to investigate whether CagA seropositivity is associated with risk of development gastric cancer. Methods: Gastric cancer group included patients with histolopathologicaly proven disease (n = 219, median of age – 66, males/females 92/127) and control group was represented by dyspeptic patients (n = 191, median of age – 56, males/females 67/124) having no evidence of gastric mucosa atrophy, evaluated according to Operative Link for Gastritis Assessment (OLGA) with score 0-I. HP seropositivity was determined using anti-HP IgG (Biohit, Finland) and antiCagA IgG, IgM and IgA (Vector BEST, Russia). Statistical test used – v2 . Results: Rate of HP seropositivity among gastric cancer patients was significantly highar compared to control group (77.2 % vs 64.4%, p = 0.03). Compared to control group, gastric cancer patients had significantly higher rate of anti-CagA seropositivity (44% vs 58.9%, OR = 1.8, CI 95% = 1.23–2.70, p = 0.002). Conclusions: Having HP infection positive to CagA virulence factor significantly increases risk of development of gastric cancer. However gastric cancer development process is very complex and interaction of host and HP factors should be studied precisely. Acknowledgements: Study was supported by ERDF project Nr.2010/0302/ 2DP/2.1.1.1.0/10/APIA/VIAA/158.",

author = "Liene Vanaga and Ilva Daugule and Georgijs Moisejevs and Dace Rudzite and Sergey Krotov and Dainius Janciauskas and Inta Liepniece-Karele and Sergejs Isajevs and Armands Sivins and Ilze Kikuste and Guntis Ancans and Konrads Funka and Ieva Lasina and Ivars Tolmanis and Aigars Vanags and Marcis Leja",

year = "2013",

month = sep,

language = "English",

volume = "18",

pages = "152--153",

journal = "Helicobacter",

issn = "1083-4389",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "Suppl.1",

note = "XXVIth International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer ; Conference date: 12-09-2013 Through 14-09-2013",

url = "https://www.nutricion.ucr.ac.cr/index.php/es/proyectos/publicaciones/376-geographic-origin-of-helicobacter-pylori-isolated-from-costa-rican-patients-european-helicobacter-study-group-xxvith-international-workshop-on-helicobacter-and-related-bacteria-in-chronic-digestive-inflammation-and-gastric-cancer",

}

TY - JOUR

T1 - CAGA ASSOCIATION WITH GASTRIC CANCER DEVELOPMENT RISK

AU - Vanaga, Liene

AU - Daugule, Ilva

AU - Moisejevs, Georgijs

AU - Rudzite, Dace

AU - Krotov, Sergey

AU - Janciauskas, Dainius

AU - Liepniece-Karele, Inta

AU - Isajevs, Sergejs

AU - Sivins, Armands

AU - Kikuste, Ilze

AU - Ancans, Guntis

AU - Funka, Konrads

AU - Lasina, Ieva

AU - Tolmanis, Ivars

AU - Vanags, Aigars

AU - Leja, Marcis

N1 - Conference code: 26

PY - 2013/9

Y1 - 2013/9

N2 - Introduction: Helicobacter pylori (HP) infection is known risk factor for development gastric cancer. One of the most studied virulence factors is cytotoxin associated gene (cagA). The aim of this study was to investigate whether CagA seropositivity is associated with risk of development gastric cancer. Methods: Gastric cancer group included patients with histolopathologicaly proven disease (n = 219, median of age – 66, males/females 92/127) and control group was represented by dyspeptic patients (n = 191, median of age – 56, males/females 67/124) having no evidence of gastric mucosa atrophy, evaluated according to Operative Link for Gastritis Assessment (OLGA) with score 0-I. HP seropositivity was determined using anti-HP IgG (Biohit, Finland) and antiCagA IgG, IgM and IgA (Vector BEST, Russia). Statistical test used – v2 . Results: Rate of HP seropositivity among gastric cancer patients was significantly highar compared to control group (77.2 % vs 64.4%, p = 0.03). Compared to control group, gastric cancer patients had significantly higher rate of anti-CagA seropositivity (44% vs 58.9%, OR = 1.8, CI 95% = 1.23–2.70, p = 0.002). Conclusions: Having HP infection positive to CagA virulence factor significantly increases risk of development of gastric cancer. However gastric cancer development process is very complex and interaction of host and HP factors should be studied precisely. Acknowledgements: Study was supported by ERDF project Nr.2010/0302/ 2DP/2.1.1.1.0/10/APIA/VIAA/158.

AB - Introduction: Helicobacter pylori (HP) infection is known risk factor for development gastric cancer. One of the most studied virulence factors is cytotoxin associated gene (cagA). The aim of this study was to investigate whether CagA seropositivity is associated with risk of development gastric cancer. Methods: Gastric cancer group included patients with histolopathologicaly proven disease (n = 219, median of age – 66, males/females 92/127) and control group was represented by dyspeptic patients (n = 191, median of age – 56, males/females 67/124) having no evidence of gastric mucosa atrophy, evaluated according to Operative Link for Gastritis Assessment (OLGA) with score 0-I. HP seropositivity was determined using anti-HP IgG (Biohit, Finland) and antiCagA IgG, IgM and IgA (Vector BEST, Russia). Statistical test used – v2 . Results: Rate of HP seropositivity among gastric cancer patients was significantly highar compared to control group (77.2 % vs 64.4%, p = 0.03). Compared to control group, gastric cancer patients had significantly higher rate of anti-CagA seropositivity (44% vs 58.9%, OR = 1.8, CI 95% = 1.23–2.70, p = 0.002). Conclusions: Having HP infection positive to CagA virulence factor significantly increases risk of development of gastric cancer. However gastric cancer development process is very complex and interaction of host and HP factors should be studied precisely. Acknowledgements: Study was supported by ERDF project Nr.2010/0302/ 2DP/2.1.1.1.0/10/APIA/VIAA/158.

M3 - Meeting Abstract

SN - 1083-4389

VL - 18

SP - 152

EP - 153

JO - Helicobacter

JF - Helicobacter

IS - Suppl.1

M1 - P18.12

T2 - XXVIth International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer

Y2 - 12 September 2013 through 14 September 2013

ER -