CAGA ASSOCIATION WITH GASTRIC CANCER DEVELOPMENT RISK

Liene Vanaga, Ilva Daugule, Georgijs Moisejevs, Dace Rudzite, Sergey Krotov, Dainius Janciauskas, Inta Liepniece-Karele, Sergejs Isajevs, Armands Sivins, Ilze Kikuste, Guntis Ancans, Konrads Funka, Ieva Lasina, Ivars Tolmanis, Aigars Vanags, Marcis Leja

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Introduction: Helicobacter pylori (HP) infection is known risk factor for development gastric cancer. One of the most studied virulence factors is cytotoxin associated gene (cagA). The aim of this study was to investigate whether CagA seropositivity is associated with risk of development gastric cancer. Methods: Gastric cancer group included patients with histolopathologicaly proven disease (n = 219, median of age – 66, males/females 92/127) and control group was represented by dyspeptic patients (n = 191, median of age – 56, males/females 67/124) having no evidence of gastric mucosa atrophy, evaluated according to Operative Link for Gastritis Assessment (OLGA) with score 0-I. HP seropositivity was determined using anti-HP IgG (Biohit, Finland) and antiCagA IgG, IgM and IgA (Vector BEST, Russia). Statistical test used – v2 . Results: Rate of HP seropositivity among gastric cancer patients was significantly highar compared to control group (77.2 % vs 64.4%, p = 0.03). Compared to control group, gastric cancer patients had significantly higher rate of anti-CagA seropositivity (44% vs 58.9%, OR = 1.8, CI 95% = 1.23–2.70, p = 0.002). Conclusions: Having HP infection positive to CagA virulence factor significantly increases risk of development of gastric cancer. However gastric cancer development process is very complex and interaction of host and HP factors should be studied precisely. Acknowledgements: Study was supported by ERDF project Nr.2010/0302/ 2DP/2.1.1.1.0/10/APIA/VIAA/158.
Original languageEnglish
Article numberP18.12
Pages (from-to)152-153
JournalHelicobacter
Volume18
Issue numberSuppl.1
Publication statusPublished - Sep 2013
EventXXVIth International Workshop on Helicobacter and
Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer
- Madrid, Spain
Duration: 12 Sep 201314 Sep 2013

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

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