Introduction: Helicobacter pylori (HP) infection is known risk factor for development gastric cancer. One of the most studied virulence factors is cytotoxin
associated gene (cagA). The aim of this study was to investigate whether CagA
seropositivity is associated with risk of development gastric cancer.
Methods: Gastric cancer group included patients with histolopathologicaly
proven disease (n = 219, median of age – 66, males/females 92/127) and control group was represented by dyspeptic patients (n = 191, median of age – 56,
males/females 67/124) having no evidence of gastric mucosa atrophy, evaluated
according to Operative Link for Gastritis Assessment (OLGA) with score 0-I. HP
seropositivity was determined using anti-HP IgG (Biohit, Finland) and antiCagA IgG, IgM and IgA (Vector BEST, Russia). Statistical test used – v2
Results: Rate of HP seropositivity among gastric cancer patients was significantly highar compared to control group (77.2 % vs 64.4%, p = 0.03). Compared to control group, gastric cancer patients had significantly higher rate of
anti-CagA seropositivity (44% vs 58.9%, OR = 1.8, CI 95% = 1.23–2.70,
p = 0.002).
Conclusions: Having HP infection positive to CagA virulence factor significantly increases risk of development of gastric cancer. However gastric cancer development process is very complex and interaction of host and HP factors
should be studied precisely.
Acknowledgements: Study was supported by ERDF project Nr.2010/0302/
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