Methods: Patient sample included dyspeptic individuals with histolopathologicaly proven any grade gastric corpus atrophy (GCA) (n = 119, median of age-69, males/females-44/75) and patients with histolopathologicaly proven non-cardia gastric cancer (GC) (n = 186, median of age-66, males/females-123/63). Control group was represented by dyspeptic patients with hyperemic gastropathy (HG) at endoscopy and no evidence of GCA or GC (n = 743, median of age-53, males/females-513/230). HP seropositivity was determined using anti-HP IgG (Biohit,Finland) and anti-CagA IgG, IgM and IgA (Vector BEST, Russia). In dubious cases presence of HP infection was evaluated also by rapid urease test and histology. Statistical test used-v2; logistic regression.
Results: CagA seropositivity was significantly higher in GCA group compared to the control group: 70% (49/70) versus 45% (332/743); p = 0.004.HP seropositivity was significantly higher in (GC) patients compared to control group:76% (141/186) versus 60% (448/743); p = 0.0001, but CagA positivity didn’t differ significantly between the groups:53% (99/186) versus 45% (332/743); p = 0.54. Among GC patients 3% (6/186) were HP negative/CagA seropositive, among GCA patients – 8% (9/70),in control group – 7% (49/743) patients were HP negative/CagA seropositive.In logistic regression analysis presence of GCA was associated with the age>50 years (OR = 2.65; 95% CI:1.68–4.18; p = 0.0001) and CagA seropositivity(OR = 1.71; 95% CI:1.14–2.55, p = 0.004).Presence of GC was significantly associated with male gender (OR = 4.35; 95% CI:3.1–6.2; p = 0.001) and HP seropositvity(OR = 1.58; 95%CI: 1.06–2.35; p = 0.015).
Conclusions: CagA seropositivity was independently associated with increased risk of GCA,while showed no association with GC in the present patient sample. It could be explained by loss of infection in some patients due to atrophy, as demonstrated by HP negative/CagA seropositive individuals in all groups of patients.
|Publication status||Published - Sep 2014|
|Event||27th European Helicobacter and Microbiota Study Group (EHMSG) International Workshop: on Helicobacter & Microbiota in Inflammation & Cancer - Rome, Italy|
Duration: 11 Sep 2014 → 13 Sep 2014
Conference number: 27
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
- 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database