CAGA SEROPOSITIVITY IN RELATION TO GASTRIC CORPUS ATROPHY AND GASTRIC CANCER

Liene Vanaga, Ilva Daugule, Georgijs Moisejevs, Dace Rudzite, Sergey Krotov, Dainius Janciauskas, Inta Liepniece-Karele, Sergejs Isajevs, Armands Sivins, Ilze Kikuste, Guntis Ancans, Konrads Funka, Ieva Lasina, Ivars Tolmanis, Aigars Vanags, Marcis Leja

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Introduction: Infection with cytotoxin associated gene (cagA) positive Helicobacter pylori(HP) strain possibly leads to development of gastric ulcers, gastric atrophy and gastric cancer.The aim of this study was analyze the association of HP and CagA positivity with presence of gastric atrophy and gastric cancer.
Methods: Patient sample included dyspeptic individuals with histolopathologicaly proven any grade gastric corpus atrophy (GCA) (n = 119, median of age-69, males/females-44/75) and patients with histolopathologicaly proven non-cardia gastric cancer (GC) (n = 186, median of age-66, males/females-123/63). Control group was represented by dyspeptic patients with hyperemic gastropathy (HG) at endoscopy and no evidence of GCA or GC (n = 743, median of age-53, males/females-513/230). HP seropositivity was determined using anti-HP IgG (Biohit,Finland) and anti-CagA IgG, IgM and IgA (Vector BEST, Russia). In dubious cases presence of HP infection was evaluated also by rapid urease test and histology. Statistical test used-v2; logistic regression.
Results: CagA seropositivity was significantly higher in GCA group compared to the control group: 70% (49/70) versus 45% (332/743); p = 0.004.HP seropositivity was significantly higher in (GC) patients compared to control group:76% (141/186) versus 60% (448/743); p = 0.0001, but CagA positivity didn’t differ significantly between the groups:53% (99/186) versus 45% (332/743); p = 0.54. Among GC patients 3% (6/186) were HP negative/CagA seropositive, among GCA patients – 8% (9/70),in control group – 7% (49/743) patients were HP negative/CagA seropositive.In logistic regression analysis presence of GCA was associated with the age>50 years (OR = 2.65; 95% CI:1.68–4.18; p = 0.0001) and CagA seropositivity(OR = 1.71; 95% CI:1.14–2.55, p = 0.004).Presence of GC was significantly associated with male gender (OR = 4.35; 95% CI:3.1–6.2; p = 0.001) and HP seropositvity(OR = 1.58; 95%CI: 1.06–2.35; p = 0.015).
Conclusions: CagA seropositivity was independently associated with increased risk of GCA,while showed no association with GC in the present patient sample. It could be explained by loss of infection in some patients due to atrophy, as demonstrated by HP negative/CagA seropositive individuals in all groups of patients.
Original languageEnglish
Article numberP18.21
Pages (from-to)165
JournalHelicobacter
Volume19
Issue numberSuppl.1
Publication statusPublished - Sep 2014
EventXXVIIth International Workshop on Helicobacter and Microbiota in Chronic Digestive Inflammation and Gastric Cancer - Rome, Italy
Duration: 11 Sep 201413 Sep 2014

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

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