TY - JOUR
T1 - Can a mother’s polycystic ovary syndrome (PCOS)-related symptoms be used to predict the future clinical profile of PCOS in her adolescent daughter? A pilot study
AU - Lidaka, Lasma
AU - Grasmane, Adele
AU - Lazdane, Gunta
AU - Dzivite-Krisane, Iveta
AU - Gailite, Linda
AU - Viberga, Ilze
N1 - Funding Information:
The study was financially supported by a Riga Stradins University internal research grant.
Publisher Copyright:
© 2020 The European Society of Contraception and Reproductive Health.
PY - 2021
Y1 - 2021
N2 - Objective: The aim of the study was to establish whether a mother’s polycystic ovary syndrome (PCOS) symptoms can predict her daughter’s future PCOS clinical profile. Methods: This was a cross-sectional study of 57 adolescents who attended a paediatric gynaecology clinic between 2017 and 2019 and had an established diagnosis of PCOS according to the 2018 criteria of the European Society of Human Reproduction and Embryology. A clinical examination and pelvic ultrasound were performed and the level of total testosterone was measured. A structured questionnaire concerning PCOS symptoms was completed by the girls’ mothers. Results: It was found that 51% of girls with PCOS and 44% of their mothers had an elevated body mass index (BMI), and 35% of girls had an increased waist–hip ratio (>0.85). The mother’s BMI significantly predicted her daughter’s BMI and waist–hip ratio. It was reported that 40% of mothers had experienced menstrual irregularities, 50% hirsutism and 67% acne, and 12% had a confirmed diagnosis of PCOS. Conclusion: Our study population had several markers of poor metabolic health (increased BMI and waist–hip ratio) that were passed down from mother to daughter. No direct link was found between a mother’s PCOS symptoms and those of her adolescent daughter. In order to establish definitive links between the symptoms of a mother and those of her daughter, a more comprehensive study should be conducted using a larger study sample. Additionally, a follow-up assessment of our studied adolescents would be appropriate to evaluate the progress of their symptoms.
AB - Objective: The aim of the study was to establish whether a mother’s polycystic ovary syndrome (PCOS) symptoms can predict her daughter’s future PCOS clinical profile. Methods: This was a cross-sectional study of 57 adolescents who attended a paediatric gynaecology clinic between 2017 and 2019 and had an established diagnosis of PCOS according to the 2018 criteria of the European Society of Human Reproduction and Embryology. A clinical examination and pelvic ultrasound were performed and the level of total testosterone was measured. A structured questionnaire concerning PCOS symptoms was completed by the girls’ mothers. Results: It was found that 51% of girls with PCOS and 44% of their mothers had an elevated body mass index (BMI), and 35% of girls had an increased waist–hip ratio (>0.85). The mother’s BMI significantly predicted her daughter’s BMI and waist–hip ratio. It was reported that 40% of mothers had experienced menstrual irregularities, 50% hirsutism and 67% acne, and 12% had a confirmed diagnosis of PCOS. Conclusion: Our study population had several markers of poor metabolic health (increased BMI and waist–hip ratio) that were passed down from mother to daughter. No direct link was found between a mother’s PCOS symptoms and those of her adolescent daughter. In order to establish definitive links between the symptoms of a mother and those of her daughter, a more comprehensive study should be conducted using a larger study sample. Additionally, a follow-up assessment of our studied adolescents would be appropriate to evaluate the progress of their symptoms.
KW - Adolescents
KW - mother–daughter correlation
KW - polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=85089078617&partnerID=8YFLogxK
U2 - 10.1080/13625187.2020.1795118
DO - 10.1080/13625187.2020.1795118
M3 - Article
AN - SCOPUS:85089078617
SN - 1362-5187
VL - 26
SP - 17
EP - 22
JO - European Journal of Contraception and Reproductive Health Care
JF - European Journal of Contraception and Reproductive Health Care
IS - 1
ER -