Case-control study of patients with essential tremor in Latvia

I. Inashkina; I. Radovica; L. Smeltere; E. Vitols; E. Jankevics

doi:10.1111/j.1468-1331.2008.02225.x

Case-control study of patients with essential tremor in Latvia

I. Inashkina, I. Radovica, L. Smeltere, E. Vitols, E. Jankevics

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ²= 2.8, P = 0.25).

Original language	English
Pages (from-to)	988-990
Number of pages	3
Journal	European Journal of Neurology
Volume	15
Issue number	9
DOIs	https://doi.org/10.1111/j.1468-1331.2008.02225.x
Publication status	Published - Sept 2008
Externally published	Yes

Keywords*

Case-control
Essential tremor
Short tandem repeat

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1111/j.1468-1331.2008.02225.x

https://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2008.02225.x

Cite this

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title = "Case-control study of patients with essential tremor in Latvia",

abstract = "Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ2 = 2.8, P = 0.25).",

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author = "I. Inashkina and I. Radovica and L. Smeltere and E. Vitols and E. Jankevics",

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doi = "10.1111/j.1468-1331.2008.02225.x",

language = "English",

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TY - JOUR

T1 - Case-control study of patients with essential tremor in Latvia

AU - Inashkina, I.

AU - Radovica, I.

AU - Smeltere, L.

AU - Vitols, E.

AU - Jankevics, E.

PY - 2008/9

Y1 - 2008/9

N2 - Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ2 = 2.8, P = 0.25).

AB - Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ2 = 2.8, P = 0.25).

KW - Case-control

KW - Essential tremor

KW - Short tandem repeat

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U2 - 10.1111/j.1468-1331.2008.02225.x

DO - 10.1111/j.1468-1331.2008.02225.x

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Case-control study of patients with essential tremor in Latvia

Abstract

Keywords*

Field of Science*

Publication Type*

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