Case-control study of patients with essential tremor in Latvia

I. Inashkina, I. Radovica, L. Smeltere, E. Vitols, E. Jankevics

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. Methods: We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. Results: No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. Conclusion: There was not a significant difference in genotypic distribution between disease group and control subjects (χ2 = 2.8, P = 0.25).

Original languageEnglish
Pages (from-to)988-990
Number of pages3
JournalEuropean Journal of Neurology
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2008
Externally publishedYes

Keywords*

  • Case-control
  • Essential tremor
  • Short tandem repeat

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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