Abstract
Background & Objective: Aberrant antigen expression in malignant
plasma cells play a role in the prognosis of multiple myeloma (MM)
(Ngo, et al., 2009; Chang et al., 2007). One of the most common complications of MM is chronic kidney disease (CKD). The aim of the study
is to investigate the relationship between the CD56, Cyclin D1, p53 and
p21 antigen expression in myeloma cells and renal function of patients
with MM.
Method: Bone marrow biopsies from 122 patients with primary diagnosed MM were examined with CyclinD1, p53, p21, CD56 antibodies.
Kidney function was evaluated by MDRD formula and estimated glomerular filtration (eGFR) rate was calculated.
Results: p53 expression in myeloma cells correlated with elevated
levels of creatinine level (p=0.018; r=0.21) and reduced eGFR
(p=0.021; r=-0.21). Patients with p53 positive (+) myeloma cells
had higher eGFR in comparison to patients with p53 negative (-)
myeloma cells (Mean±SD, 66.7±44.5 vs 84.7±46.9 mL/min,
p=0.021, Mann-Whitney U-test). CD56 expression in myeloma
cells correlates with elevated eGFR (pgroup with CD56 + myeloma cells had lower eGFR in comparison to patients with CD56 (-) myeloma cells (87.4±47.1 vs 45.8±
26.7 mL/min, passociation was found between CyclinD1, and p21 expression
with eGFR.
Conclusion: MM patients with CD56 negative and p53 positive expression in myeloma cells had worst kidney function assessed by eGFR and
as a result more advanced CKD stage and therefore it implied a graver
prognosis of MM
plasma cells play a role in the prognosis of multiple myeloma (MM)
(Ngo, et al., 2009; Chang et al., 2007). One of the most common complications of MM is chronic kidney disease (CKD). The aim of the study
is to investigate the relationship between the CD56, Cyclin D1, p53 and
p21 antigen expression in myeloma cells and renal function of patients
with MM.
Method: Bone marrow biopsies from 122 patients with primary diagnosed MM were examined with CyclinD1, p53, p21, CD56 antibodies.
Kidney function was evaluated by MDRD formula and estimated glomerular filtration (eGFR) rate was calculated.
Results: p53 expression in myeloma cells correlated with elevated
levels of creatinine level (p=0.018; r=0.21) and reduced eGFR
(p=0.021; r=-0.21). Patients with p53 positive (+) myeloma cells
had higher eGFR in comparison to patients with p53 negative (-)
myeloma cells (Mean±SD, 66.7±44.5 vs 84.7±46.9 mL/min,
p=0.021, Mann-Whitney U-test). CD56 expression in myeloma
cells correlates with elevated eGFR (pgroup with CD56 + myeloma cells had lower eGFR in comparison to patients with CD56 (-) myeloma cells (87.4±47.1 vs 45.8±
26.7 mL/min, passociation was found between CyclinD1, and p21 expression
with eGFR.
Conclusion: MM patients with CD56 negative and p53 positive expression in myeloma cells had worst kidney function assessed by eGFR and
as a result more advanced CKD stage and therefore it implied a graver
prognosis of MM
| Original language | English |
|---|---|
| Article number | E-PS-10-022 |
| Pages (from-to) | S269-S269 |
| Number of pages | 1 |
| Journal | Virchows Archiv |
| Volume | 473 |
| Issue number | Suppl. 1 |
| Publication status | Published - Sept 2018 |
| Externally published | Yes |
| Event | 30th European Congress of Pathology - Bilbao, Spain Duration: 8 Sept 2018 → 12 Sept 2018 Conference number: 30 http://30th European Congress of Pathology https://www.esp-congress.org/_Resources/Persistent/a23726a91bec6a46d17327186473e87b0b6d510f/ECP2019_First%20Announcement.pdf https://easl.eu/event/31st-european-congress-of-pathology/ |
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
Publication Type*
- 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database