Cell proliferation and apoptosis in wistar rat kidney after renal mass ablation and low-dose irradiation

Marina Aunapuu, Andres Arend, Mai Ots, Mara Pilmane

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated. Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9). Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation. Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.

Original languageEnglish
Pages (from-to)204-210
Number of pages7
JournalMedicina
Volume46
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • Apoptosis
  • Cell proliferation
  • Low-dose radiation
  • Rat
  • Remnant kidney

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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