Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia

Nauris Zdanovskis (Coresponding Author), Ardis Platkājis, Andrejs Kostiks, Oļesja Grigorjeva, Guntis Karelis

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Abstract

The cerebellum is commonly viewed as a structure that is primarily responsible for the
coordination of voluntary movement, gait, posture, and speech. Recent research has shown evidence
that the cerebellum is also responsible for cognition. We analyzed 28 participants divided into three
groups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severe
cognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellar
cortex and white matter volume and assessed differences between groups. Participants with normal
cognition had higher average values in total cerebellar volume, cerebellar white matter volume, and
cerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did not
find these values to be statistically significant.
Original languageEnglish
Article number1134
JournalBrain Sciences
Volume11
DOIs
Publication statusPublished - 26 Aug 2021

Keywords*

  • cerebellum
  • cortex
  • volumetry
  • MRI
  • dementia
  • cognitive impairment
  • white matter

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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