Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia

Nauris Zdanovskis; Ardis Platkājis; Andrejs Kostiks; Oļesja Grigorjeva; Guntis Karelis

doi:10.3390/brainsci11091134

Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia

Nauris Zdanovskis (Corresponding Author), Ardis Platkājis, Andrejs Kostiks, Oļesja Grigorjeva, Guntis Karelis

Department of Radiology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

23 Downloads (Pure)

Abstract

The cerebellum is commonly viewed as a structure that is primarily responsible for the
coordination of voluntary movement, gait, posture, and speech. Recent research has shown evidence
that the cerebellum is also responsible for cognition. We analyzed 28 participants divided into three
groups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severe
cognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellar
cortex and white matter volume and assessed differences between groups. Participants with normal
cognition had higher average values in total cerebellar volume, cerebellar white matter volume, and
cerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did not
find these values to be statistically significant.

Original language	English
Article number	1134
Journal	Brain Sciences
Volume	11
DOIs	https://doi.org/10.3390/brainsci11091134
Publication status	Published - 26 Aug 2021

Keywords*

cerebellum
cortex
volumetry
MRI
dementia
cognitive impairment
white matter

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3390/brainsci11091134Licence: CC BY

Cerebellar Cortex and Cerebellar White Matter VolumeFinal published version, 1.26 MBLicence: CC BY

Cite this

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title = "Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia",

abstract = "The cerebellum is commonly viewed as a structure that is primarily responsible for thecoordination of voluntary movement, gait, posture, and speech. Recent research has shown evidencethat the cerebellum is also responsible for cognition. We analyzed 28 participants divided into threegroups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severecognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellarcortex and white matter volume and assessed differences between groups. Participants with normalcognition had higher average values in total cerebellar volume, cerebellar white matter volume, andcerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did notfind these values to be statistically significant.",

keywords = "cerebellum, cortex, volumetry, MRI, dementia, cognitive impairment, white matter",

author = "Nauris Zdanovskis and Ardis Platkājis and Andrejs Kostiks and Oļesja Grigorjeva and Guntis Karelis",

note = "Funding Information: Funding: The article has been developed with financing from the European Social Fund and the state budget within the project no. 8.2.2.0/20/I/004 “Support for involving doctoral students in sci‐ entific research and studies”. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = aug,

day = "26",

doi = "10.3390/brainsci11091134",

language = "English",

volume = "11",

journal = "Brain Sciences",

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AU - Zdanovskis, Nauris

AU - Platkājis, Ardis

AU - Kostiks, Andrejs

AU - Grigorjeva, Oļesja

AU - Karelis, Guntis

N1 - Funding Information: Funding: The article has been developed with financing from the European Social Fund and the state budget within the project no. 8.2.2.0/20/I/004 “Support for involving doctoral students in sci‐ entific research and studies”. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/8/26

Y1 - 2021/8/26

N2 - The cerebellum is commonly viewed as a structure that is primarily responsible for thecoordination of voluntary movement, gait, posture, and speech. Recent research has shown evidencethat the cerebellum is also responsible for cognition. We analyzed 28 participants divided into threegroups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severecognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellarcortex and white matter volume and assessed differences between groups. Participants with normalcognition had higher average values in total cerebellar volume, cerebellar white matter volume, andcerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did notfind these values to be statistically significant.

AB - The cerebellum is commonly viewed as a structure that is primarily responsible for thecoordination of voluntary movement, gait, posture, and speech. Recent research has shown evidencethat the cerebellum is also responsible for cognition. We analyzed 28 participants divided into threegroups (9 with normal cognition, 9 with mild cognitive impairment, and 10 with moderate/severecognitive impairment) based on the Montreal Cognitive Assessment. We analyzed the cerebellarcortex and white matter volume and assessed differences between groups. Participants with normalcognition had higher average values in total cerebellar volume, cerebellar white matter volume, andcerebellar cortex volume in both hemispheres, but by performing the Kruskal–Wallis test, we did notfind these values to be statistically significant.

KW - cerebellum

KW - cortex

KW - volumetry

KW - MRI

KW - dementia

KW - cognitive impairment

KW - white matter

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DO - 10.3390/brainsci11091134

M3 - Article

SN - 2076-3425

VL - 11

JO - Brain Sciences

JF - Brain Sciences

M1 - 1134

ER -

Cerebellar Cortex and Cerebellar White Matter Volume in Normal Cognition, Mild Cognitive Impairment, and Dementia

Abstract

Keywords*

Field of Science*

Publication Type*

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