Abstract
Objectives The present study aims to present the current trends in emergence of multidrug resistant nosocomial strains of Enterococci species at P.Stradiņš Hospital in Latvia.
Materials and Methods Bacterial isolates were collected from 2,478 patients admitted in different departments in Paul Stradins Clinical University Hospital over the course of four years from 2017 to 2020. All clinical samples like pus, blood, urine etc. were inoculated on appropriate media and species identification was done using Vitek2 analyzer or MALDI-TOFF. Antimicrobial susceptibility was assessed disk diffusion test according latest EUCAST recommendations. Statistical analysis was done using Excel and R.
Results E. faecalis was the most common isolated species followed by E. faecium with both species showing a significant increase (P < 0.05) in occurrence in Period 2 (2019-20) when compared with Period 1 (2017-18). Co-infection by both species also saw a significant rise in Period 2. Strains of both species showed a decrease in anti-microbial resistance towards ampicillin, ciprofloxacin and norfloxacin. Whilst E. faecalis showed a decrease in resistance towards gentamycin, vancomycin and nitrofurantion, E. faecium showed the opposite trend. A decrease was also noted for Linezolid. Other isolated species like E. avium and E. raffinosus showed increased occurrence as well increase in resistance to tested antibiotics.
Conclusions Drifting trends in anti-microbial resistance pose a substantial challenge in clinical practice. Proper and effective infection control is essential for determining the outcome of clinical treatment along with impeding the emergence of multi-drug resistant strains.
Materials and Methods Bacterial isolates were collected from 2,478 patients admitted in different departments in Paul Stradins Clinical University Hospital over the course of four years from 2017 to 2020. All clinical samples like pus, blood, urine etc. were inoculated on appropriate media and species identification was done using Vitek2 analyzer or MALDI-TOFF. Antimicrobial susceptibility was assessed disk diffusion test according latest EUCAST recommendations. Statistical analysis was done using Excel and R.
Results E. faecalis was the most common isolated species followed by E. faecium with both species showing a significant increase (P < 0.05) in occurrence in Period 2 (2019-20) when compared with Period 1 (2017-18). Co-infection by both species also saw a significant rise in Period 2. Strains of both species showed a decrease in anti-microbial resistance towards ampicillin, ciprofloxacin and norfloxacin. Whilst E. faecalis showed a decrease in resistance towards gentamycin, vancomycin and nitrofurantion, E. faecium showed the opposite trend. A decrease was also noted for Linezolid. Other isolated species like E. avium and E. raffinosus showed increased occurrence as well increase in resistance to tested antibiotics.
Conclusions Drifting trends in anti-microbial resistance pose a substantial challenge in clinical practice. Proper and effective infection control is essential for determining the outcome of clinical treatment along with impeding the emergence of multi-drug resistant strains.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - Nov 2020 |
| Event | XV Baltic Congress in Laboratory Medicine - online Zoom, Riga, Latvia Duration: 6 Nov 2020 → 7 Nov 2020 Conference number: 15 https://www.balmriga.com/ |
Congress
| Congress | XV Baltic Congress in Laboratory Medicine |
|---|---|
| Abbreviated title | BALM 2020 |
| Country/Territory | Latvia |
| City | Riga |
| Period | 6/11/20 → 7/11/20 |
| Internet address |
Keywords*
- Enterococci
- antimicrobial resistance
- Nosocomial infection
Field of Science*
- 3.1 Basic medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)