Chemical composition and biological activity of extracts from aerial parts of wild and cultivated Glechoma hederacea L.

Valerija Krizhanovska, Inga Sīle, Arta Kronberga, Ilva Nakurte, Ieva Mezaka, Maija Dambrova, Osvalds Pugovics, Solveiga Grinberga

Research output: Contribution to conferencePoster

Abstract

Glechoma hederacea has been used as a traditional medicine for centuries in the treatment of various ailments, including cold, gastric diseases, diabetes, and inflammation. The aim of the study was to compare the chemical composition and biological activity of aqueous ethanol extracts of wild and cultivated G. hederacea. The qualitative and quantitative analysis of the extracts was performed using LC-MS methods. The antiradical activity was measured using the DPPH assay and the total phenolic content was tested using the Folin-Ciocalteu method. The expression of CD80 and CD86 in bone marrow-derived macrophages was examined by flow cytometry analysis. Rosmarinic acid, chlorogenic acid and caffeic acid were the main compounds identified in the extracts of G. hederacea. Nine compounds not previously observed were tentatively identified. The antiradical activity and the total phenolic content in the extracts were higher after harvesting in the later stage of vegetative growth (July – September). The extracts of G. hederacea significantly decreased the
LPS-induced expression of double positive CD80 and CD86 cells. The composition of the G. hederacea extracts was found to depend on the site of collection and the conditions of plant growth, however, the main factor that affected the chemical composition was the harvest time.
Original languageEnglish
Number of pages5
Publication statusPublished - 2021
Event8th European Virtual Congress of Pharmacology (EPHAR 2021) - Virtual
Duration: 6 Dec 20218 Dec 2021
Conference number: 8
https://www.ephar2021.org/

Congress

Congress8th European Virtual Congress of Pharmacology (EPHAR 2021)
Abbreviated titleEPHAR 2021
Period6/12/218/12/21
Internet address

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 6. Other publications

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