Abstract
Glechoma hederacea has been used as a traditional medicine for centuries in the treatment of various ailments, including cold, gastric diseases, diabetes, and inflammation. The aim of the study was to compare the chemical composition and biological activity of aqueous ethanol extracts of wild and cultivated G. hederacea. The qualitative and quantitative analysis of the extracts was performed using LC-MS methods. The antiradical activity was measured using the DPPH assay and the total phenolic content was tested using the Folin-Ciocalteu method. The expression of CD80 and CD86 in bone marrow-derived macrophages was examined by flow cytometry analysis. Rosmarinic acid, chlorogenic acid and caffeic acid were the main compounds identified in the extracts of G. hederacea. Nine compounds not previously observed were tentatively identified. The antiradical activity and the total phenolic content in the extracts were higher after harvesting in the later stage of vegetative growth (July – September). The extracts of G. hederacea significantly decreased the
LPS-induced expression of double positive CD80 and CD86 cells. The composition of the G. hederacea extracts was found to depend on the site of collection and the conditions of plant growth, however, the main factor that affected the chemical composition was the harvest time.
LPS-induced expression of double positive CD80 and CD86 cells. The composition of the G. hederacea extracts was found to depend on the site of collection and the conditions of plant growth, however, the main factor that affected the chemical composition was the harvest time.
Original language | English |
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Number of pages | 5 |
Publication status | Published - 2021 |
Event | 8th European Virtual Congress of Pharmacology (EPHAR 2021) - Virtual Duration: 6 Dec 2021 → 8 Dec 2021 Conference number: 8 https://www.ephar2021.org/ |
Congress
Congress | 8th European Virtual Congress of Pharmacology (EPHAR 2021) |
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Abbreviated title | EPHAR 2021 |
Period | 6/12/21 → 8/12/21 |
Internet address |
Field of Science*
- 3.1 Basic medicine
Publication Type*
- 6. Other publications