Chordoma: To know means to recognize

Emija Nikola Karele, Anda Nikola Paze (Coresponding Author)

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management.

Original languageEnglish
Article number188796
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Issue number5
Publication statusPublished - Sept 2022
Externally publishedYes


  • Bone tumor
  • Brachyury
  • Chordoma
  • Diagnostics
  • Neuropathology
  • Radiotherapy

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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