Chordoma: To know means to recognize

Emija Nikola Karele; Anda Nikola Paze

doi:10.1016/j.bbcan.2022.188796

Chordoma: To know means to recognize

Emija Nikola Karele
, Anda Nikola Paze (Corresponding Author)

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management.

Original language	English
Article number	188796
Journal	Biochimica et Biophysica Acta - Reviews on Cancer
Volume	1877
Issue number	5
DOIs	https://doi.org/10.1016/j.bbcan.2022.188796
Publication status	Published - Sept 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

Bone tumor
Brachyury
Chordoma
Diagnostics
Neuropathology
Radiotherapy

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.bbcan.2022.188796

Cite this

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title = "Chordoma: To know means to recognize",

abstract = "Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management.",

keywords = "Bone tumor, Brachyury, Chordoma, Diagnostics, Neuropathology, Radiotherapy",

author = "Karele, \{Emija Nikola\} and Paze, \{Anda Nikola\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = sep,

doi = "10.1016/j.bbcan.2022.188796",

language = "English",

volume = "1877",

journal = "Biochimica et Biophysica Acta - Reviews on Cancer",

issn = "0304-419X",

publisher = "Elsevier B.V.",

number = "5",

}

TY - JOUR

T1 - Chordoma

T2 - To know means to recognize

AU - Karele, Emija Nikola

AU - Paze, Anda Nikola

PY - 2022/9

Y1 - 2022/9

N2 - Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management.

AB - Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine. Chordoma grows slowly, therefore its insidious onset leads to delayed diagnosis, accounting for the low survival rates. Treatment centers around successful en bloc resection with negative margins, though, considering the anatomically constrained site of growth, it frequently requires adjuvant radiotherapy. This article analyzes the existing literature with the aim to provide a better insight in the current state of research in chordoma classification, characteristics, and management.

KW - Bone tumor

KW - Brachyury

KW - Chordoma

KW - Diagnostics

KW - Neuropathology

KW - Radiotherapy

UR - https://www.scopus.com/pages/publications/85138169165

U2 - 10.1016/j.bbcan.2022.188796

DO - 10.1016/j.bbcan.2022.188796

M3 - Review article

C2 - 36089204

AN - SCOPUS:85138169165

SN - 0304-419X

VL - 1877

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

IS - 5

M1 - 188796

ER -

Chordoma: To know means to recognize

Abstract

UN SDGs

Keywords*

Field of Science*

Publication Type*

Access to Document

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