Abstract
Metastatic dissemination of the primary tumor
is the major cause of death in colorectal cancer (CRC)
patients. Multiple chromosomal breaks and chromothripsis, a
phenomenon involving multiple chromosomal fragmentations
occurring in a single catastrophic event, are associated with
cancer genesis, progression and developing of metastases. The
aim of this study was to evaluate the effect of chromothripsis
and total breakpoint count (breakpoint instability index)
on progression-free survival (PFS). A total of 19 patients
with metastatic CRC (mCRC) receiving FOLFOX first‑line
palliative chemotherapy between August, 2011 and October,
2012 were selected for this study. The results indicated that
the highest breakpoint count was observed in chromosomes
1, 2 and 6. Chromothripsis was detected in 52.6% of the study
patients. Furthermore, chromothripsis was associated with an
increased median PFS (mPFS; 14 vs. 8 months, respectively;
P=0.03), but an association with overall survival was not identified. The present study demonstrated that chromothripsis
affected CRC patient survival, suggesting a role for this event
as a prognostic and predictive marker in mCRC treatment.
is the major cause of death in colorectal cancer (CRC)
patients. Multiple chromosomal breaks and chromothripsis, a
phenomenon involving multiple chromosomal fragmentations
occurring in a single catastrophic event, are associated with
cancer genesis, progression and developing of metastases. The
aim of this study was to evaluate the effect of chromothripsis
and total breakpoint count (breakpoint instability index)
on progression-free survival (PFS). A total of 19 patients
with metastatic CRC (mCRC) receiving FOLFOX first‑line
palliative chemotherapy between August, 2011 and October,
2012 were selected for this study. The results indicated that
the highest breakpoint count was observed in chromosomes
1, 2 and 6. Chromothripsis was detected in 52.6% of the study
patients. Furthermore, chromothripsis was associated with an
increased median PFS (mPFS; 14 vs. 8 months, respectively;
P=0.03), but an association with overall survival was not identified. The present study demonstrated that chromothripsis
affected CRC patient survival, suggesting a role for this event
as a prognostic and predictive marker in mCRC treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 182-186 |
| Number of pages | 5 |
| Journal | Molecular and Clinical Oncology |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2017 |
Keywords*
- metastatic colorectal cancer
- chromothripsis
- breakpoint instability index
- progression-free survival
Field of Science*
- 3.2 Clinical medicine
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
