Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

N. Osna; G. Silonova; N. Vilgert; E. Hagina; V. Kuse; V. Giedraitis; A. Zvirbliene; M. Mauricas; A. Sochnev

doi:10.3109/00365519709105232

Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

N. Osna, G. Silonova, N. Vilgert, E. Hagina, V. Kuse, V. Giedraitis, A. Zvirbliene, M. Mauricas, A. Sochnev

Rīga Stradiņš University

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.

Original language	English
Pages (from-to)	703-710
Number of pages	8
Journal	Scandinavian Journal of Clinical and Laboratory Investigation
Volume	57
Issue number	8
DOIs	https://doi.org/10.3109/00365519709105232
Publication status	Published - 1997

Keywords*

Chronic hepatitis C
Interferon gamma
Interleukin 10
Interleukin 12
Interleukin 4

Field of Science*

1.4 Chemical sciences
1.6 Biological sciences
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/00365519709105232

https://www.tandfonline.com/doi/abs/10.3109/00365519709105232

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title = "Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood",

abstract = "Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.",

keywords = "Chronic hepatitis C, Interferon gamma, Interleukin 10, Interleukin 12, Interleukin 4",

author = "N. Osna and G. Silonova and N. Vilgert and E. Hagina and V. Kuse and V. Giedraitis and A. Zvirbliene and M. Mauricas and A. Sochnev",

year = "1997",

doi = "10.3109/00365519709105232",

language = "English",

volume = "57",

pages = "703--710",

journal = "Scandinavian Journal of Clinical and Laboratory Investigation",

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TY - JOUR

T1 - Chronic hepatitis C

T2 - T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

AU - Osna, N.

AU - Silonova, G.

AU - Vilgert, N.

AU - Hagina, E.

AU - Kuse, V.

AU - Giedraitis, V.

AU - Zvirbliene, A.

AU - Mauricas, M.

AU - Sochnev, A.

PY - 1997

Y1 - 1997

N2 - Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.

AB - Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.

KW - Chronic hepatitis C

KW - Interferon gamma

KW - Interleukin 10

KW - Interleukin 12

KW - Interleukin 4

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U2 - 10.3109/00365519709105232

DO - 10.3109/00365519709105232

M3 - Article

C2 - 9458493

AN - SCOPUS:0031463331

SN - 0036-5513

VL - 57

SP - 703

EP - 710

JO - Scandinavian Journal of Clinical and Laboratory Investigation

JF - Scandinavian Journal of Clinical and Laboratory Investigation

IS - 8

ER -

Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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