Abstract
Interferon gamma (IFNγ) and interleukin 4, 10 and 12 (IL-4, -10, -12) production was measured in whole peripheral blood (WPB) and peripheral blood mononuclear cells (PBMC) of 10 chronic hepatitis C (CHC) patients. The level of IFNγ in supernatants in mitogen-activated WPB was lower than in healthy donors. IL-10 served as a possible downregulative factor for IFNγ, since its spontaneous IL-10 production was enhanced in CHC. Neutralization of IL-10 partly restored IFNγ response in CHC patients. Recombinant IL-12 (rIL-12) also enhanced IFNγ of CHC patients, but IL-12 production was decreased in CHC. Thus, IFNγ production deficiency in CHC patients is secondary to blockage by high levels of IL-10-impaired IL-12 production.
| Original language | English |
|---|---|
| Pages (from-to) | 703-710 |
| Number of pages | 8 |
| Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
| Volume | 57 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1997 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords*
- Chronic hepatitis C
- Interferon gamma
- Interleukin 10
- Interleukin 12
- Interleukin 4
Field of Science*
- 1.6 Biological sciences
- 3.2 Clinical medicine
- 1.4 Chemical sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
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