TY - JOUR
T1 - Chronic Intestinal Failure in Children
T2 - An International Multicenter Cross-Sectional Survey
AU - Lezo, Antonella
AU - Diamanti, Antonella
AU - Marinier, Evelyne M.
AU - Tabbers, Merit
AU - Guz-Mark, Anat
AU - Gandullia, Paolo
AU - Spagnuolo, Maria I.
AU - Protheroe, Sue
AU - Peretti, Noel
AU - Merras-Salmio, Laura
AU - Hulst, Jessie M.
AU - Kolaček, Sanja
AU - Ee, Looi C.
AU - Lawrence, Joanna
AU - Hind, Jonathan
AU - D’antiga, Lorenzo
AU - Verlato, Giovanna
AU - Pukite, Ieva
AU - Di Leo, Grazia
AU - Vanuytsel, Tim
AU - Doitchinova-Simeonova, Maryana K.
AU - Ellegard, Lars
AU - Masconale, Luisa
AU - Maíz-Jiménez, María
AU - Cooper, Sheldon C.
AU - Brillanti, Giorgia
AU - Nardi, Elena
AU - Sasdelli, Anna S.
AU - Lal, Simon
AU - Pironi, Loris
N1 - Funding Information:
Funding: The project of the ESPEN database for Chronic Intestinal Failure was promoted by the ESPEN Executive Committee in 2013, was approved by the ESPEN Council and was supported by an ESPEN grant.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children.
AB - Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1–4 and 14–18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children.
KW - body growth
KW - children
KW - chronic intestinal failure
KW - home parenteral nutrition
KW - intestinal transplantation
KW - intravenous supplementation
KW - transition
UR - http://www.scopus.com/inward/record.url?scp=85129205577&partnerID=8YFLogxK
U2 - 10.3390/nu14091889
DO - 10.3390/nu14091889
M3 - Article
C2 - 35565856
AN - SCOPUS:85129205577
SN - 2072-6643
VL - 14
JO - Nutrients
JF - Nutrients
IS - 9
M1 - 1889
ER -