Circulating sestrins and force velocity profiling in older adults with type 2 diabetes

Raquel González-Martos, Raquel Aparicio-Ugarriza, Julian Alcazar, Carmen Ramirez-Castillejo, Dace Reihmane, Adrian Menéndez-Rey, Marcela González-Gross, Amelia Guadalupe-Grau (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Type 2 diabetes mellitus (T2DM) in old age affects the musculoskeletal system causing loss of muscle mass, strength, and physical function. Stress-inducible proteins named sestrins are potential novel biomarkers of muscle function due to their ability to suppress oxidative stress and prevent muscle degeneration. Our aim was to determine the association between different force-velocity (F-V) profiles with body composition, physical performance, and glucose control in older adults with T2DM. We also intended to determine the potential utility of sestrin 1 (Sesn1) and 2 (Sesn2) as biomarkers of physical functionality. Fifty-nine participants (69–79 years) were classified in 3 groups according to their F-V profile based on the leg press exercise: nondeficit (NDEF= 40.7%), force deficit (FDEF= 28.8%), and velocity deficit (VDEF= 30.5%). Both VDEF and FDEF groups showed lower muscle power than NDEF (Cohen’s d 0.87 and 0.75 for effect size, respectively). Serum Sesn2 levels, maximal dynamic strength, arms and legs fat-free mass were reduced in FDEF compared to the NDEF group (p < 0.05), whereas glycated haemoglobin (HbA1c) and fasting glucose levels were similar among groups. ROC analysis revealed the distinction between the NDEF and FDEF group based on Sesn2 concentrations (<0.72 ng/mL), suggesting their potential use as functional biomarkers for early intervention through exercise. Older adults with T2DM show different F-V profiles, related to low levels of Sesn2, impaired body composition and physical performance, and may be taken into consideration to target exercise training in this specific population. Highlights The influence of different F-V deficit profiles on body composition, physical function and circulating sestrins in older adults with type 2 diabetes were studied. Both force and velocity deficits negatively affected muscle power. Force deficits are associated to low circulating sestrin 2 levels and regional fat-free mass. Basal serum sestrin 2 levels are potential biomarkers to characterise F-V profiles.

Original languageEnglish
Number of pages10
JournalEuropean Journal of Sport Science
Publication statusAccepted/In press - 2022


  • aging
  • biochemistry
  • body composition
  • musculoskeletal
  • Performance

Field of Science*

  • 3.3 Health sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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