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Abstract
Objectives:
Gallbladder cancer (GBC), though rare, is an aggressive malignancy with a poor prognosis, comprising 80–95% of all hepatobiliary cancers. The aim of the study was to analyze the clinical and histopathological features of GBC treated at a tertiary referral hospital in Latvia.
Materials and Methods:
A retrospective analysis of 26 patients treated at the Riga East University Hospital with histologically confirmed GBC between 2019 and 2024.
Results:
The mean age at diagnosis was 69 years (range 63-77.5), with a male-to-female ratio of 1:3. Emergency admission was required in 9 (34.6%) patients. The most common initial presentation of tumor was RUQ pain (53.8%), followed by jaundice (26.9%), cholangitis (3.8%) and other nonspecific symptoms (23.1%). Radiological assessment showed gallbladder wall thickening and gallbladder mass in 4 (15.4%) and 12 (46.2%) patients, respectively. In addition, gallstone disease was identified in 13 (50%) patients. Stage IV disease was confirmed in 50%, and distant metastases were observed in 11 (42.3%) patients. Notably, GBC was not suspected in half of patients in the preoperative examination. Simple cholecystectomy was performed in 17 (65.4%) patients, of whom 13 (50%) had acute cholecystitis, while 4 (15.4%) underwent surgery for histological tumor verification. Nine patients (34.6%) underwent extended surgical resection. Moreover, 4 (15.4%) patients underwent additional re-resection following initial cholecystectomy. Negative surgical margins were achieved at 76.9%. The
pathology analysis revealed adenocarcinoma in 24 (92.3%), squamous cell carcinoma in 1 (3.8%), and NET in 2 (3.8%) patients. 7.7% of all tumors were Grade I, 73.1% - Grade II, 19.2% - Grade III. Adjuvant chemotherapy was administered to 11 (42.3%) patients. Overall, 19 (73.1%) patients died during the study period.
Conclusions:
GBC is a rare and aggressive malignancy often diagnosed at advanced stages. In our study half of GBC were incidentally diagnosed following cholecystectomy, highlighting the challenges of early disease detection.
Gallbladder cancer (GBC), though rare, is an aggressive malignancy with a poor prognosis, comprising 80–95% of all hepatobiliary cancers. The aim of the study was to analyze the clinical and histopathological features of GBC treated at a tertiary referral hospital in Latvia.
Materials and Methods:
A retrospective analysis of 26 patients treated at the Riga East University Hospital with histologically confirmed GBC between 2019 and 2024.
Results:
The mean age at diagnosis was 69 years (range 63-77.5), with a male-to-female ratio of 1:3. Emergency admission was required in 9 (34.6%) patients. The most common initial presentation of tumor was RUQ pain (53.8%), followed by jaundice (26.9%), cholangitis (3.8%) and other nonspecific symptoms (23.1%). Radiological assessment showed gallbladder wall thickening and gallbladder mass in 4 (15.4%) and 12 (46.2%) patients, respectively. In addition, gallstone disease was identified in 13 (50%) patients. Stage IV disease was confirmed in 50%, and distant metastases were observed in 11 (42.3%) patients. Notably, GBC was not suspected in half of patients in the preoperative examination. Simple cholecystectomy was performed in 17 (65.4%) patients, of whom 13 (50%) had acute cholecystitis, while 4 (15.4%) underwent surgery for histological tumor verification. Nine patients (34.6%) underwent extended surgical resection. Moreover, 4 (15.4%) patients underwent additional re-resection following initial cholecystectomy. Negative surgical margins were achieved at 76.9%. The
pathology analysis revealed adenocarcinoma in 24 (92.3%), squamous cell carcinoma in 1 (3.8%), and NET in 2 (3.8%) patients. 7.7% of all tumors were Grade I, 73.1% - Grade II, 19.2% - Grade III. Adjuvant chemotherapy was administered to 11 (42.3%) patients. Overall, 19 (73.1%) patients died during the study period.
Conclusions:
GBC is a rare and aggressive malignancy often diagnosed at advanced stages. In our study half of GBC were incidentally diagnosed following cholecystectomy, highlighting the challenges of early disease detection.
| Original language | English |
|---|---|
| Pages | 212-212 |
| Number of pages | 1 |
| Publication status | Published - Mar 2025 |
| Event | RSU Research Week 2025: Knowledge for Use in Practice - Riga Stradiņš university, Riga, Latvia Duration: 26 Mar 2025 → 28 Mar 2025 https://rw2025.rsu.lv/conferences/knowledge-use-practice |
Conference
| Conference | RSU Research Week 2025: Knowledge for Use in Practice |
|---|---|
| Country/Territory | Latvia |
| City | Riga |
| Period | 26/03/25 → 28/03/25 |
| Other | Infections in the Development of Non-Communicable Diseases |
| Internet address |
Keywords*
- Gallbladder cancer
- Hepatobilliary cancers
- Cholecystectomy
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
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Dive into the research topics of 'Clinical Characteristics and Treatment of Gallbladder Cancer: 5-Year Retrospective Analysis from Tertiary Referral Hospital'. Together they form a unique fingerprint.Research output
- 1 Book
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Rīga Stradiņš University International Research Conference on Medical and Health Care Sciences “Knowledge for Use in Practice”: Abstracts, 26-28 March, 2025
Rīga Stradiņš University, 2025, Rīga: Rīga Stradiņš University. 478 p.Research output: Book/Report › Book
Open Access