TY - JOUR
T1 - Clinical Characteristics of Actinic Keratosis Associated with the Risk of Progression to Invasive Squamous Cell Carcinoma
T2 - A Systematic Review
AU - Balcere, Alise
AU - Konrāde-Jilmaza, Laura
AU - Pauliņa, Laura Agnese
AU - Čēma, Ingrīda
AU - Krūmiņa, Angelika
N1 - Funding Information:
This research and the APC were funded by ESF project no. 8.2.2.0/20/I/004 “Support for involving doctoral students in scientific research and studies” at Riga Stradiņš University.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/8/28
Y1 - 2022/8/28
N2 - Background: Actinic keratosis (AK) is one of the most common lesions on chronically sun-damaged skin that has the risk of progression to invasive squamous cell carcinoma (SCC). With the possibilities of using digital technologies for following-up skin lesions and their increased use in the past few decades, our objective was to update the review by Quaedvlieg et al., 2006, and to review prospective studies from 2005 onwards to identify the clinical characteristics of AK that later progressed to SCC. Methods: The PubMed, Scopus, and ScienceDirect databases were searched for relevant articles. The search had the following criteria: English language, human subjects and year from 2005 onwards. The study protocol was registered in the Prospero database with the record number CRD42020200429 and followed the PRISMA guidelines. The risk-of-bias assessment was performed using the QUIPS tool. Results: From the 5361 studies screened, 105 reports were evaluated for eligibility, and 2 articles with 621 patients were included. The main AK types associated with the development of SCC were found to be baseline AK, also known as a long-standing AK, and merging AK, also called an “AK patch”.
AB - Background: Actinic keratosis (AK) is one of the most common lesions on chronically sun-damaged skin that has the risk of progression to invasive squamous cell carcinoma (SCC). With the possibilities of using digital technologies for following-up skin lesions and their increased use in the past few decades, our objective was to update the review by Quaedvlieg et al., 2006, and to review prospective studies from 2005 onwards to identify the clinical characteristics of AK that later progressed to SCC. Methods: The PubMed, Scopus, and ScienceDirect databases were searched for relevant articles. The search had the following criteria: English language, human subjects and year from 2005 onwards. The study protocol was registered in the Prospero database with the record number CRD42020200429 and followed the PRISMA guidelines. The risk-of-bias assessment was performed using the QUIPS tool. Results: From the 5361 studies screened, 105 reports were evaluated for eligibility, and 2 articles with 621 patients were included. The main AK types associated with the development of SCC were found to be baseline AK, also known as a long-standing AK, and merging AK, also called an “AK patch”.
KW - AK patch
KW - baseline AK
KW - keratinocyte cancer
KW - merging AK
KW - progression
UR - http://www.scopus.com/inward/record.url?scp=85139797794&partnerID=8YFLogxK
U2 - 10.3390/jcm11195899
DO - 10.3390/jcm11195899
M3 - Review article
C2 - 36233766
AN - SCOPUS:85139797794
SN - 2077-0383
VL - 11
JO - Journal of clinical medicine
JF - Journal of clinical medicine
IS - 19
M1 - 5899
ER -
