Clinical characteristics of patients with tick-borne encephalitis (Tbe): A European multicentre study from 2010 to 2017

Benno Kohlmaier, Nina A. Schweintzger, Manfred G. Sagmeister, Vendula Švendová, Daniela S. Kohlfürst, Astrid Sonnleitner, Manuel Leitner, Andrea Berghold, Erich Schmiedberger, Franz Fazekas, Alexander Pichler, Jana Rejc-Marko, Daniel Růžek, Lucie Dufková, Darina Čejková, Petr Husa, Martina Pýchová, Lenka Krbková, Václav Chmelík, Věra ŠtruncováDace Zavadska, Guntis Karelis, Aukse Mickiene, Joanna Zajkowska, Petra Bogovič, Franc Strle, Werner Zenz (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)
60 Downloads (Pure)


Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.

Original languageEnglish
Article number1420
Issue number7
Publication statusPublished - Jul 2021


  • Central paresis
  • Meningomyelitis
  • Peripheral paresis
  • Tick-borne encephalitis
  • Vaccine-preventable disease

Field of Science*

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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