Clinical experience with intravenous zoledronic acid in the treatment of male osteoporosis: Evidence and opinions

Ieva Ruza, Sasan Mirfakhraee, Eric Orwoll, Ugis Gruntmanis (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Osteoporosis frequently remains underrecognized and undertreated in men. Most osteoporosis-related fractures could be prevented if men at risk would be diagnosed, treated, and remained compliant with therapy. Bisphosphonates, the mainstay of osteoporosis treatment, are potent antiresorptive agents that inhibit osteoclast activity, suppress in vivo markers of bone turnover, increase bone mineral density, decrease fractures, and likely improve survival in men with osteoporosis. The focus of the article is on intravenous zoledronic acid, which may be a preferable alternative to oral bisphosphonate therapy in patients with cognitive dysfunction, the inability to sit upright, polypharmacy, significant gastrointestinal pathology or suspected medication noncompliance. Zoledronic acid is approved in the United States (US) and European Union (EU) as an annual 5 mg intravenous infusion to treat osteoporosis in men. The zoledronic acid 4 mg intravenous dose has been studied in the prevention of bone loss associated with androgen deprivation therapy. This article reviews the evidence for zoledronic acid, currently the most potent bisphosphonate available for clinical use, and its therapeutic effects in the treatment of men with osteoporosis.

Original languageEnglish
Pages (from-to)182-198
Number of pages17
JournalTherapeutic Advances in Musculoskeletal Disease
Issue number4
Publication statusPublished - Aug 2013
Externally publishedYes


  • bisphosphonates
  • bone mineral density
  • fracture
  • men
  • osteoporosis
  • zoledronic acid

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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