Colorectal adenomas in patients under age of 50

The incidence of colorectal cancer, especially located in distal colorectum, is rising markedly in young patients. Conventional adenomas have been widely recognised as precursors of colorectal cancer. The aim of this study is to investigate the correlation of polyp features and location in patients under age of 50. Adult out-patients under the age 50 who received colonoscopy were included in the study from Sep 1 2020 to Nov 30 2020. Clinical data including number, location, size and histopathology of polyps were collected. Polyp detecion rate was calculated as 27,4%. Advanced adenomas were defined as ≥3 adenomas, size ≥10 mm, villous pattern or high grade displasia. In total, 190 patients - 55% female and 45% male patients aged 18 - 49, with the mean age- 47 were enrolled in the study. In total 52 polyps were detected in the studied group, with polyp detection rate of 27,4%. 36 (19% patients) had at least one polyp. 21(11% patients) had 24 conventional adenomas. 17 (71%) of all adenomas were located in left colon. 11 (46%) of all adenomas were detected in patients aged 45-49. The detection rate of advanced adenomas was higher in patients aged 45-49. Among patients under age 50 advanced adenomas were predominantly located in the left colon. Advanced adenomas more often were found in patients aged 45-49. Those results could explain the rising trend of left colon cancer in young adults and update the topicality for colonoscopy screening in this population. Results of this study comply with the results of other studies that suggest a need for screening colonoscopy in age group 45-50.