Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion

Katarīna Gurkina; Zoltan Mark Horvath; Ruslans  Kačanovs; Valentyn Mohylyuk

doi:10.13140/RG.2.2.24155.94240

Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion

Katarīna Gurkina
, Zoltan Mark Horvath
, Ruslans Kačanovs
, Valentyn Mohylyuk (Corresponding Author)

Lead Researcher Group

Research output: Contribution to conference › Poster › peer-review

Original language	English
Number of pages	1
DOIs	https://doi.org/10.13140/RG.2.2.24155.94240
Publication status	Published - 24 Mar 2026
Event	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - Prague Congress Centre, Prague, Czech Republic Duration: 23 Mar 2026 → 26 Mar 2026 Conference number: 15 https://worldmeeting.org/

Meeting

Meeting	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Abbreviated title	PBP World meeting
Country/Territory	Czech Republic
City	Prague
Period	23/03/26 → 26/03/26
Internet address	https://worldmeeting.org/

Keywords*

preformulation
formulation
Amorphous solid dispersions
precipitation
Dissolution
solubility parameters
boiling point
residual solvents
solubility

Field of Science*

1.4 Chemical sciences
2.4 Chemical engineering
2.5 Materials engineering
3.1 Basic medicine

Publication Type*

3.4. Other publications in conference proceedings (including local)

Access to Document

10.13140/RG.2.2.24155.94240Licence: CC BY

https://www.linkedin.com/feed/update/urn:li:activity:7442902364711186433

Ternary Phase Diagrams of Naproxen with Soluplus® and Chloroform or Ethyl Acetate
Horvath, Z. M., Gurkina, K., Bērziņš, A., Viter, R. & Mohylyuk, V. (Corresponding Author), 24 Mar 2026. 1 p.
Research output: Contribution to conference › Poster › peer-review

Open Access
Amorphous solid dispersion tablet active coating in a perforated pan coater: proof of concept
Raciborska, L., Buczkowska, E. M., Kukuls, K. & Mohylyuk, V. (Corresponding Author), 1 Oct 2025. 1 p.
Research output: Contribution to conference › Poster
High drug-loaded amorphous solid dispersions of a poor glass forming drug: The impact of polymer type and cooling rate on amorphous drug behaviour
Kolisnyk, T., Mohylyuk, V., Fil, N., Bickerstaff, E., Li, S., Jones, D. S. & Andrews, G. P. (Corresponding Author), 10 Feb 2025, In: International Journal of Pharmaceutics. 670, 125095.
Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus)

Elucidation of the mechanism of amorphization and dissolution of bad glass former as a function of drug-polymer interaction and preparation method
Mohylyuk, V. (Project leader), Viter, R. (Partner's coordinator), Žogota, M. (Assistant (student)), Horvath, Z. M. (Expert), Kukuls, K. (Expert), Gurkina, K. (Assistant (student)), Bērziņš, A. (Expert), Zabolotnii, V. (Assistant (student)) & Borovskis, A. (Assistant (student))
Latvian Council of Science
1/01/25 → 31/12/27
Project: Fundamental and Applied Research Programme

Elucidation of the mechanism of amorphization and dissolution of bad glass formers as a function of drug-polymer interaction and preparation method: Toward sustainable technologies
Mohylyuk, V. (Speaker), Viter, R. (Co-author) & Bērziņš, A. (Co-author)
16 Apr 2026
Activity: Talk or presentation types › Oral presentation

News > Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion
Gurkina, K., Horvath, Z. M., Kačanovs, R. & Mohylyuk, V.
6/04/26
1 item of Media coverage
Press/Media

Cite this

Gurkina, K., Horvath, Z. M., Kačanovs, R., & Mohylyuk, V. (2026). Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic. https://doi.org/10.13140/RG.2.2.24155.94240

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title = "Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion",

keywords = "preformulation, formulation, Amorphous solid dispersions, precipitation, Dissolution, solubility parameters, boiling point, residual solvents, solubility",

author = "Katarīna Gurkina and Horvath, \{Zoltan Mark\} and Ruslans Ka{\v c}anovs and Valentyn Mohylyuk",

year = "2026",

month = mar,

day = "24",

doi = "10.13140/RG.2.2.24155.94240",

language = "English",

note = "15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, PBP World meeting ; Conference date: 23-03-2026 Through 26-03-2026",

url = "https://worldmeeting.org/",

}

Gurkina, K , Horvath, ZM, Kačanovs, R & Mohylyuk, V 2026, 'Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion', 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic, 23/03/26 - 26/03/26. https://doi.org/10.13140/RG.2.2.24155.94240

Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion. / Gurkina, Katarīna ; Horvath, Zoltan Mark; Kačanovs, Ruslans et al.
2026. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion

AU - Gurkina, Katarīna

AU - Horvath, Zoltan Mark

AU - Kačanovs, Ruslans

AU - Mohylyuk, Valentyn

N1 - Conference code: 15

PY - 2026/3/24

Y1 - 2026/3/24

KW - preformulation

KW - formulation

KW - Amorphous solid dispersions

KW - precipitation

KW - Dissolution

KW - solubility parameters

KW - boiling point

KW - residual solvents

KW - solubility

U2 - 10.13140/RG.2.2.24155.94240

DO - 10.13140/RG.2.2.24155.94240

M3 - Poster

T2 - 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Y2 - 23 March 2026 through 26 March 2026

ER -

Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion

Meeting

Keywords*

Field of Science*

Publication Type*

Access to Document

Research output

Ternary Phase Diagrams of Naproxen with Soluplus® and Chloroform or Ethyl Acetate

Amorphous solid dispersion tablet active coating in a perforated pan coater: proof of concept

High drug-loaded amorphous solid dispersions of a poor glass forming drug: The impact of polymer type and cooling rate on amorphous drug behaviour

Projects

Elucidation of the mechanism of amorphization and dissolution of bad glass former as a function of drug-polymer interaction and preparation method

Activities

Elucidation of the mechanism of amorphization and dissolution of bad glass formers as a function of drug-polymer interaction and preparation method: Toward sustainable technologies

Press/Media

News > Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion

Cite this