Comparing Charlson and Elixhauser comorbidity indices in treated and untreated Inflammatory bowel disease

Research output: Contribution to conferenceAbstractpeer-review


Inflammatory bowel diseases (IBD) are frequently accompanied by comorbidities due to systemic autoimmune process, however it is not clear how IBD treatment impacts burden of comorbidities. The aim of the study was to quantify burden of comorbidities in treated and not treated IBD patients.
Population of incident IBD patients from Latvian National Health Service reimbursed medicines database matched on age and gender was analyzed for the period of 2014-2018, with follow up (FUP) till 2019.
Incident patients with IBD (ICD-10 code K50 and K51) were identified in the reimbursed medicines database as individuals with at least 5 reimbursed medicines prescriptions, and with at least 3 months of treatment.
Relative control group - patients having only 1 prescription for IBD, as these are patients who were not adherent to IBD therapy or initially misdiagnosed with IBD. To determine comorbidity burden Charlson (CCI) and Elixhauser (ECI) comorbidity indices were used. Samples were analyzed using Welch Two Sample t-test. Correlation between CCI and ECI was assessed using Pearson's correlation test.
187 CD (age 10–88 years) and 1137 UC (age 1-95) incident patients and equivalent number of controls were included into analysis. In treated and untreated CD patients CCI and ECI at start was similar, p>0.05. At the end of FUP treated CD patients had significantly lower CCI and ECI than untreated CD patients - CCI - 0.60 (SD 1.11) vs 0.94 (SD 1.37), p=0.010; ECI 2.1 (SD 4.0) vs 3.2 (SD 5.1), p=0.019. For UC untreated patients had higher both CCI and ECI at start
Treated IBD patients have lower comorbidity burden than untreated IBD controls. Very strong correlation between CCI and ECI is observed.
Original languageEnglish
Publication statusPublished - 11 Dec 2022
EventWorld congress of Gastroenterology (WCOG) 2022 - Dubai Conventional centre, Dubai, United Arab Emirates
Duration: 10 Dec 202214 Dec 2022


CongressWorld congress of Gastroenterology (WCOG) 2022
Abbreviated titleWCOG 2022
Country/TerritoryUnited Arab Emirates
Internet address

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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