Comparison between diffusion-weighted sequences with selective and non-selective fat suppression in the evaluation of Crohn's disease activity : are they equally useful?

Ilze Apine (Coresponding Author), Reinis Pitura, Ivanda Franckevica, Juris Pokrotnieks, Gaida Krūmiņa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We compared the efficiency of two MRI diffusion weighted imaging (DWI) techniques: DWI with SPIR (DWI SPIR) and DWI with STIR (DWI STIR), to estimate their eligibility for quantitative assessment of Crohn's disease activity in children and adults. Methods: In inflamed terminal ileum segments ( n = 32 in adults, n = 46 in children), Magnetic Resonance Index of Activity (MaRIA) was calculated, ADC values of both DWI techniques were measured, and the corresponding Clermont scores calculated. ADC values of both DWI techniques were compared between both and within each patient group, assessing their mutual correlation. Correlations between MaRIA and the corresponding ADC values, and Clermont scores based on both DWI techniques were estimated. Results: No correlation between ADC of DWI SPIR and DWI STIR was observed (rho = 0.27, p = 0.13 in adults, rho = 0.20, p = 0.17 in children). The correlation between MaRIA and Clermont scores was strong in both techniques-in SPIR, rho = 0.93; p < 0.0005 in adults, rho = 0.98, p < 0.0005 in children, and, in STIR, rho = 0.89; p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children. The correlation between ADC and MaRIA was moderate negative for DWI STIR (rho = 0.93, p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children), but, in DWI STIR, no correlation between ADC and MaRIA score was observed in adults (rho = -0.001, p = 0.99), whereas children presented low negative correlation (rho = -0.374, p = 0.01). Conclusions: DWI STIR is not suitable for quantitative assessment of Crohn's disease activity both in children and adult patients.

Original languageEnglish
Article number347
JournalDiagnostics
Volume10
Issue number6
DOIs
Publication statusPublished - 27 May 2020

Keywords

  • ADC
  • Clermont score
  • DWI
  • DWI fat suppression techniques
  • DWIBS
  • MR enterography
  • MaRIA
  • diffusion-weighted imaging
  • terminal ileitis

Field of Science

  • 3.2 Clinical medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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