Comparison of clinical features of Kawasaki disease, toxic shock syndrome and multisystem inflammatory syndrome in children

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Backgrounds: The COVID-19 pandemic has brought numerous challenges. One of them is multisystem
inflammatory syndrome in children (MIS-C), developing two to six weeks after acute SARS-CoV-2
infection. This study aimed to describe the clinical characteristics of patients who met the criteria for MIS-
C, and compare them with the features of Kawasaki disease (KD) and toxic shock syndrome (TSS).
Methods: This retrospective study was conducted at the Children's Clinical University Hospital in Riga,
Latvia, and involved children with MIS-C, KD or TSS. Clinical data was collected from medical records and analysed using descriptive
parametric and non-parametric statistics. A statistically significant difference between groups was
assumed where p value Results: In all, 81 children were included in the study: 39 (48.1%) with KD (mean age 3.9 (SD 3.7) years;
23 boys (59%)), 29 (35.8%) with MIS-C (mean age 9.8 (SD 4.5) years; 16 boys (55.2%)) and 13 (16.1%)
with TSS (mean age 11.3 (SD 5.2) years; 5 boys (38.5%)). The time from symptom onset to diagnosis
was shorter in TSS compared with MIS-C and KD (pKD, with more frequent gastrointestinal symptoms (e.g., abdominal pain, vomitting, diarrhoea),
neurological manifestations (e.g., headache, meningism/photophobia, hyperaesthesia) and cardiac
involvement at onset (i.e., valvular insufficiency, pericardial effusions, systolic dysfunction)(pMeanwhile, cervical lymphadenopathy, synovitis and arthralgia were significantly more common in KD
compared with MIS-C and TSS (pConclusions/Learning Points: Children with MIS-C display specific clinical features when compared
with those with KD and TSS. The overlapping signs and symptoms of these childhood diseases make an
appropriate diagnosis challenging.
Original languageEnglish
Pages97
Publication statusPublished - 2022
Event40th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID) - Athens & online, Athens, Greece
Duration: 9 May 202213 May 2022
Conference number: 40
https://2022.espidmeeting.org/

Meeting

Meeting40th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID)
Abbreviated titleESPID 2022
Country/TerritoryGreece
CityAthens
Period9/05/2213/05/22
Internet address

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)

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