Abstract
Backgrounds: The COVID-19 pandemic has brought numerous challenges. One of them is multisystem
inflammatory syndrome in children (MIS-C), developing two to six weeks after acute SARS-CoV-2
infection. This study aimed to describe the clinical characteristics of patients who met the criteria for MIS-
C, and compare them with the features of Kawasaki disease (KD) and toxic shock syndrome (TSS).
Methods: This retrospective study was conducted at the Children's Clinical University Hospital in Riga,
Latvia, and involved children with MIS-C, KD or TSS. Clinical data was collected from medical records and analysed using descriptive
parametric and non-parametric statistics. A statistically significant difference between groups was
assumed where p value Results: In all, 81 children were included in the study: 39 (48.1%) with KD (mean age 3.9 (SD 3.7) years;
23 boys (59%)), 29 (35.8%) with MIS-C (mean age 9.8 (SD 4.5) years; 16 boys (55.2%)) and 13 (16.1%)
with TSS (mean age 11.3 (SD 5.2) years; 5 boys (38.5%)). The time from symptom onset to diagnosis
was shorter in TSS compared with MIS-C and KD (pKD, with more frequent gastrointestinal symptoms (e.g., abdominal pain, vomitting, diarrhoea),
neurological manifestations (e.g., headache, meningism/photophobia, hyperaesthesia) and cardiac
involvement at onset (i.e., valvular insufficiency, pericardial effusions, systolic dysfunction)(pMeanwhile, cervical lymphadenopathy, synovitis and arthralgia were significantly more common in KD
compared with MIS-C and TSS (pConclusions/Learning Points: Children with MIS-C display specific clinical features when compared
with those with KD and TSS. The overlapping signs and symptoms of these childhood diseases make an
appropriate diagnosis challenging.
inflammatory syndrome in children (MIS-C), developing two to six weeks after acute SARS-CoV-2
infection. This study aimed to describe the clinical characteristics of patients who met the criteria for MIS-
C, and compare them with the features of Kawasaki disease (KD) and toxic shock syndrome (TSS).
Methods: This retrospective study was conducted at the Children's Clinical University Hospital in Riga,
Latvia, and involved children with MIS-C, KD or TSS. Clinical data was collected from medical records and analysed using descriptive
parametric and non-parametric statistics. A statistically significant difference between groups was
assumed where p value Results: In all, 81 children were included in the study: 39 (48.1%) with KD (mean age 3.9 (SD 3.7) years;
23 boys (59%)), 29 (35.8%) with MIS-C (mean age 9.8 (SD 4.5) years; 16 boys (55.2%)) and 13 (16.1%)
with TSS (mean age 11.3 (SD 5.2) years; 5 boys (38.5%)). The time from symptom onset to diagnosis
was shorter in TSS compared with MIS-C and KD (pKD, with more frequent gastrointestinal symptoms (e.g., abdominal pain, vomitting, diarrhoea),
neurological manifestations (e.g., headache, meningism/photophobia, hyperaesthesia) and cardiac
involvement at onset (i.e., valvular insufficiency, pericardial effusions, systolic dysfunction)(pMeanwhile, cervical lymphadenopathy, synovitis and arthralgia were significantly more common in KD
compared with MIS-C and TSS (pConclusions/Learning Points: Children with MIS-C display specific clinical features when compared
with those with KD and TSS. The overlapping signs and symptoms of these childhood diseases make an
appropriate diagnosis challenging.
| Original language | English |
|---|---|
| Pages | 97 |
| Publication status | Published - 2022 |
| Event | 40th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID) - Athens & online, Athens, Greece Duration: 9 May 2022 → 13 May 2022 Conference number: 40 https://2022.espidmeeting.org/ |
Meeting
| Meeting | 40th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID) |
|---|---|
| Abbreviated title | ESPID 2022 |
| Country/Territory | Greece |
| City | Athens |
| Period | 9/05/22 → 13/05/22 |
| Internet address |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
