Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population

Egija Zole, Didzis Elfers, Janis Kimsis, Astrida Krumina, Kristaps Narels, Ilva Pole, Renate Ranka, Liana Pliss

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geographic location, and/or specific historic background. The aims of this study were to identify a specific hg which correlates with aging in a Latvian populating and to evaluate the possible association of TL variability with specific mitochondrial hgs. The results show no significant correlation between TL, mitochondrial DNA hgs and longevity. A slight increase in frequency was observed among centenarians of hg H; however, these findings were not statistically significant. TL did not show any statically significant difference, only hg W had slightly longer telomeres among others. An insignificant increase in TL was observed in the 55-89 age group of hg W but in the <90 age group for hg J which also had the longest TL in the 20-45 age group. In conclusion this study indicates that specific mitochondrial DNA hgs do not have a significant, if any, influence on the variation of TL in Latvians.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalMechanisms of Ageing and Development
Volume145
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Aging
  • Latvians
  • Mitochondrial haplogroups
  • Telomere length

Field of Science

  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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