Concomitant multiple sclerosis and ankylosing spondylitis: a clinical case report

Estere Zeltiņa (Coresponding Author), Liga Mekša, Anda Kadiša, Guntis Karelis, Daina Pastare, Sandra Svilpe, Elīna Polunosika, Līga Jaunozoliņa

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Background: The therapy of patients with concomitant multiple sclerosis (MS) and ankylosing spondylitis (AS) is a challenge for
clinicians. Secukinumab is effective in the treatment of MS. In the clinical case, we present, substantial clinical and radiological
remission in the case of both autoimmune diseases was observed.
Case Presentation: A male adult was diagnosed with relapsing-remitting MS. The patient complained of severe thoraco-lumbar
pain. Magnetic resonance imaging (MRI) led to a diagnosis of AS. Considering that nonsteroidal anti-inflammatory drugs were
ineffective and tumor necrosis factor-α blockers are contraindicated in patients with MS, secukinumab was prescribed. MRI 8
months after initiation of therapy provided clinical stability in consideration of the two autoimmune comorbidities.
Conclusion: Secukinumab is an effective therapy for concomitant MS and AS.
Original languageEnglish
Pages (from-to)95-101
JournalEuropean Journal of Medical Case Reports (EJMCR)
Issue number6
Publication statusPublished - 2022


  • Multiple sclerosis
  • ankylosing spondylitis
  • secukinumab
  • autoimmune disease
  • case report

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.3. Anonymously reviewed scientific article published in a journal with an international editorial board and is available in another indexed database


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