Abstract
Objectives: So far it is not clear, whether the use of Continuous veno-venous hemofiltration (CVVH) as the method of detoxification for sepsis patients does influence the indicators of recovery. CVVH in the case of sepsis is initiated before patients develop absolute indications and is being used as extracorporeal
detoxification method. Aim of study is to analyse hazard ratio of CVVH initiation for short-term (7 days) and long-term (28 days) fatal outcomes in sepsis patients.
Methods: A retrospective study of 127 patients who were treated at Riga East University Hospital with diagnosis “sepsis” during the time period from 2014 to 2017 and in whom CVVH was used. SPSS software was used to analyze data, and hazard ratio (HR) was calculated using Cox regression method.
Results: Among study patients 47.2% (60/127) were males, median of age 68 years (IQR 58–76). All patients were divided into two groups according to CVVH initiation criteria: 63/124 (49.6%) had absolute indications and 64/124 (50.4%) had relative indications. On the 7th day and on the 28th day of hospital admission survival rates for sepsis patients were 83/127 (65.4%) and 53/127 (41.7%), respectively. During all hospital length of stay survival rate of sepsis patients was 47/127 (37.0%). For the short-term and long-term outcomes initiation of CVVH based on the absolute indications was associated with higher mortality rates HR = 2.19 (95% CI 1.17–4.08) and HR = 2.08 (95% CI 1.30–3.34), respectively, in comparison to relative indications. After adjustment to other prognostic factors (sepsis origin, need of mechanical lung ventilation, SOFA score, lactate concentration etc.) only long-term higher mortality
rates showed significant association with CVVH initiation based on absolute indications HR = 1.96 (95% CI 1.08–3.56).
Conclusions: CVVH in sepsis patients based on relative indications may improve long-term patient survival by the possible ability of the method to clear cytokine storm.
detoxification method. Aim of study is to analyse hazard ratio of CVVH initiation for short-term (7 days) and long-term (28 days) fatal outcomes in sepsis patients.
Methods: A retrospective study of 127 patients who were treated at Riga East University Hospital with diagnosis “sepsis” during the time period from 2014 to 2017 and in whom CVVH was used. SPSS software was used to analyze data, and hazard ratio (HR) was calculated using Cox regression method.
Results: Among study patients 47.2% (60/127) were males, median of age 68 years (IQR 58–76). All patients were divided into two groups according to CVVH initiation criteria: 63/124 (49.6%) had absolute indications and 64/124 (50.4%) had relative indications. On the 7th day and on the 28th day of hospital admission survival rates for sepsis patients were 83/127 (65.4%) and 53/127 (41.7%), respectively. During all hospital length of stay survival rate of sepsis patients was 47/127 (37.0%). For the short-term and long-term outcomes initiation of CVVH based on the absolute indications was associated with higher mortality rates HR = 2.19 (95% CI 1.17–4.08) and HR = 2.08 (95% CI 1.30–3.34), respectively, in comparison to relative indications. After adjustment to other prognostic factors (sepsis origin, need of mechanical lung ventilation, SOFA score, lactate concentration etc.) only long-term higher mortality
rates showed significant association with CVVH initiation based on absolute indications HR = 1.96 (95% CI 1.08–3.56).
Conclusions: CVVH in sepsis patients based on relative indications may improve long-term patient survival by the possible ability of the method to clear cytokine storm.
| Original language | English |
|---|---|
| Pages | 202 |
| Number of pages | 1 |
| Publication status | Published - Apr 2019 |
| Event | RSU International Research Conference 2019: Knowledge For Use In Practice - Riga, Latvia Duration: 1 Apr 2019 → 3 Apr 2019 https://conference2019.rsu.lv/general-information/about-conference https://conference2019.rsu.lv/general-information https://www.rsu.lv/zinatnes-nedela-2019 https://conference2019.rsu.lv/sites/default/files/documents/knowledge_for_use_in_practice_abstracts_rev.pdf |
Conference
| Conference | RSU International Research Conference 2019 |
|---|---|
| Country/Territory | Latvia |
| City | Riga |
| Period | 1/04/19 → 3/04/19 |
| Other | The Conference will be held within the framework of RSU Research Week 2019. RSU starptautiskā konference "Zināšanas praksei" medicīnas un veselības aprūpes nozarē 2019. |
| Internet address |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)