TY - JOUR
T1 - Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK)
AU - Vallabh, Neeru A.
AU - Kennedy, Stephnie
AU - Vinciguerra, Riccardo
AU - McLean, Keri
AU - Levis, Hannah
AU - Borroni, Davide
AU - Romano, Vito
AU - Willoughby, Colin E.
N1 - Publisher Copyright:
© 2022 Neeru A Vallabh et al.
PY - 2022
Y1 - 2022
N2 - The corneal endothelium has a crucial role in maintaining a clear and healthy cornea. Corneal endothelial cell loss occurs naturally with age; however, a diagnosis of glaucoma and surgical intervention for glaucoma can exacerbate a decline in cell number and impairment in morphology. In glaucoma, the mechanisms for this are not well understood and this accelerated cell loss can result in corneal decompensation. Given the high prevalence of glaucoma worldwide, this review aims to explore the abnormalities observed in the corneal endothelium in differing glaucoma phenotypes and glaucoma therapies (medical or surgical including with new generation microinvasive glaucoma surgeries). Descemet membrane endothelial keratoplasty (DMEK) is increasingly being used to manage corneal endothelial failure for glaucoma patients and we aim to review the recent literature evaluating the use of this technique in this clinical scenario.
AB - The corneal endothelium has a crucial role in maintaining a clear and healthy cornea. Corneal endothelial cell loss occurs naturally with age; however, a diagnosis of glaucoma and surgical intervention for glaucoma can exacerbate a decline in cell number and impairment in morphology. In glaucoma, the mechanisms for this are not well understood and this accelerated cell loss can result in corneal decompensation. Given the high prevalence of glaucoma worldwide, this review aims to explore the abnormalities observed in the corneal endothelium in differing glaucoma phenotypes and glaucoma therapies (medical or surgical including with new generation microinvasive glaucoma surgeries). Descemet membrane endothelial keratoplasty (DMEK) is increasingly being used to manage corneal endothelial failure for glaucoma patients and we aim to review the recent literature evaluating the use of this technique in this clinical scenario.
UR - http://www.scopus.com/inward/record.url?scp=85131156176&partnerID=8YFLogxK
U2 - 10.1155/2022/1315299
DO - 10.1155/2022/1315299
M3 - Review article
AN - SCOPUS:85131156176
SN - 2090-004X
VL - 2022
JO - Journal of Ophthalmology
JF - Journal of Ophthalmology
M1 - 1315299
ER -