Corrigendum to “Inflammatory biomarkers in patients in simvastatin treatment: No effect of co-enzyme Q10 supplementation” (Cytokine (2019) 113 (393–399), (S1043466618303995), (10.1016/j.cyto.2018.10.011))

The authors regret that an error in the analytical procedure of CoQ10 concentrations in plasma has been discovered. In consequence, Section 3.2 (CoQ10 concentrations in plasma) on p. 395: “Baseline plasma CoQ10 concentrations were similar in control, statin + Q10 and statin + placebo (868 ± 62, 968 ± 29, and 962 ± 39 µg/l). Following eight weeks of supplementation plasma CoQ10 concentrations increased significantly (P < 0.05) in the statin + CoQ10 group (to 1029 ± 20 µg/l) while no change was seen in the statin + placebo group (952 ± 24 µg/l).” Should be replaced by: “Plasma CoQ10 concentrations were measured in statin + Q10 and statin + placebo groups, but not in the control group. Baseline plasma CoQ10 concentrations were similar in statin + Q10 and statin + placebo (530 ± 46 and 455 ± 42 nmol/l). Following eight weeks of supplementation plasma CoQ10 concentrations increased significantly (P < 0.05) in the statin + CoQ10 group (to 2724 ± 417 nmol/l) while no change was seen in the statin + placebo group (518 ± 59 nmol/l).” Furthermore, the methods description (p. 395) for determination of total CoQ10: “Total coenzyme Q10 levels were measured by high performance liquid chromatography (HLPC). The analyses were monitored with a UV detector set at 275 nm, a Q10 column (# 68100, Chromsystems, Gräfelfing, Germany) and a flow rate at 2.5 ml/min of the mobile phase (# 68001, Chromsystems, Gräfelfing, Germany). Coenzyme Q10 was extracted from plasma and separated from lipophilic proteins. The subsequent solution was then cleaned up and concentrated by solid phase extraction by following the instructions of the reagent kit (#68000, Chromsystems, Gräfelfing, Germany), and then the mixture (50 μl) were injected into the HPLC system. An internal standard was used to minimize analytical variations and to provide reliable quantification. A plasma standard calibrator (# 68003, Chromsystems, Gräfelfing, Germany) was analyzed to calculate the final concentration of the sample.” Should be replaced by: “Plasma CoQ10 content were assayed as described by Orlando et al. (Orlando P, Silvestri S, Galeazzi R, Antonicelli R, Marcheggiani F, Cirilli I, Bacchetti T, Tiano L. Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox Rep. 2018 Dec;23(1):136–145. doi: https://doi.org/10.1080/13510002.2018.1472924).”.>. The authors would like to apologise for any inconvenience caused.