Abstract
Introduction. Acne vulgaris [AV] is commonly considered a problem that occurs in adolescence, an increasing number
of patients over 25 years of age. According to the European guidelines for the management of acne, the treatment options differ according to the severity and clinical type of acne and can involve topical as well as systemic therapy. Bacterial resistance to antibiotics is a clinically relevant concern globally. Therefore, therapeutic options that reduce the need for topical and oral antibiotic therapy for acne are welcome.
Materials and Methods. Fourty-one individual with comedonal and mild papulopustular AV according to European Dermatology Forum and American Academy of Dermatology guidelines was enrolled in the study. The study participants were randomly split into two groups. The first group (N=17) used a test product 1 with active substances including Salicylic Acid 2%, Ilex Paraguariensis Leaf Extract 1%, Zinc PCA 0.50%, Cetraria Islandica
Extract 0.03%, Usnea Barbata Extract 0.03%, Juniperus Communis Callus Culture Extract 0.02%. The second group (N=17) used test product 2 without active substances. Thus, each group of participants used a test product with or without active substances in the morning and before going to sleep. The severity of facial acne of each participant was captured during the initial visit before applying the test product as well as during the follow up visit after 6 weeks. Images were taken from 3 perspectives: frontal and sagittal from both sides. Images were evaluated for relative changes of inflammatory and non-inflammatory lesion count. Data statistical analysis Mann Whitney U test was used to compare results from both groups and Wilcoxon Signed test was used to compare acne severity before and after 6 weeks.
Results. The study revealed that the quantity of inflammatory lesions decreased in both groups, respectively, by -39,56,
SD=82,37% in the group using test product 1, and by -2,16, SD=61,0% in the group using test product 2. The results between both groups differed significantly (p=0,013). The percentage changes in the quantity of non-inflammatory lesions did not reveal a statistically significant difference. In absolute numbers inflammatory lesion count decreased significantly (from 4,71, SD=2,23 to 2,29, SD=2,14, p=0,011). For non-inflammatory elements no statistically significant difference was revealed.
Conclusions. Topical cosmetic formulations can have a significant impact on the severity of mild acne.
of patients over 25 years of age. According to the European guidelines for the management of acne, the treatment options differ according to the severity and clinical type of acne and can involve topical as well as systemic therapy. Bacterial resistance to antibiotics is a clinically relevant concern globally. Therefore, therapeutic options that reduce the need for topical and oral antibiotic therapy for acne are welcome.
Materials and Methods. Fourty-one individual with comedonal and mild papulopustular AV according to European Dermatology Forum and American Academy of Dermatology guidelines was enrolled in the study. The study participants were randomly split into two groups. The first group (N=17) used a test product 1 with active substances including Salicylic Acid 2%, Ilex Paraguariensis Leaf Extract 1%, Zinc PCA 0.50%, Cetraria Islandica
Extract 0.03%, Usnea Barbata Extract 0.03%, Juniperus Communis Callus Culture Extract 0.02%. The second group (N=17) used test product 2 without active substances. Thus, each group of participants used a test product with or without active substances in the morning and before going to sleep. The severity of facial acne of each participant was captured during the initial visit before applying the test product as well as during the follow up visit after 6 weeks. Images were taken from 3 perspectives: frontal and sagittal from both sides. Images were evaluated for relative changes of inflammatory and non-inflammatory lesion count. Data statistical analysis Mann Whitney U test was used to compare results from both groups and Wilcoxon Signed test was used to compare acne severity before and after 6 weeks.
Results. The study revealed that the quantity of inflammatory lesions decreased in both groups, respectively, by -39,56,
SD=82,37% in the group using test product 1, and by -2,16, SD=61,0% in the group using test product 2. The results between both groups differed significantly (p=0,013). The percentage changes in the quantity of non-inflammatory lesions did not reveal a statistically significant difference. In absolute numbers inflammatory lesion count decreased significantly (from 4,71, SD=2,23 to 2,29, SD=2,14, p=0,011). For non-inflammatory elements no statistically significant difference was revealed.
Conclusions. Topical cosmetic formulations can have a significant impact on the severity of mild acne.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 62nd International Scientific Conference of Daugavpils University |
| Subtitle of host publication | Part A. Natural Sciences |
| Editors | Irēna Kokina |
| Place of Publication | Daugavpils |
| Publisher | Daugavpils University |
| Pages | 7-13 |
| ISBN (Print) | 978-9984-14-925-7 |
| Publication status | Published - 2020 |
| Event | 62nd International Scientific Conference of Daugavpils University - Daugavpils, Latvia Duration: 28 May 2020 → 29 May 2020 Conference number: 62 |
Conference
| Conference | 62nd International Scientific Conference of Daugavpils University |
|---|---|
| Country/Territory | Latvia |
| City | Daugavpils |
| Period | 28/05/20 → 29/05/20 |
| Other | Daugavpils Universitātes 62. starptautiskā zinātniskā konference |
Keywords*
- Acne vulgaris
- cosmetics
- bacterial resistance
- topical therapy
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code