TY - JOUR
T1 - Coxsackie virus B antibodies are increased in HLA DR3-MICA5.1 positive type 1 diabetes patients in the Linköping region of Sweden
AU - Gupta, Manu
AU - Nikitina-Zake, Liene
AU - Landin-Olsson, Mona
AU - Kockum, Ingrid
AU - Sanjeevi, Carani B.
N1 - Funding Information:
This work was supported by the Swedish Medical Research Council (K2001-16x-12532-04B for C.B.S., 07531 for Gisela Dahlquist), the National Institutes of Health, the Juvenile Diabetes Foundation International, the Novo Nordisk Fund for C.B.S., the Swedish Diabetes Association to C.B.S., Swedish Physicians Association, Barn Diabetes Fund to C.B.S., Swedish Institute (M.G.). C.B.S. was supported by Swedish MFR's position (K2001-72P-13149-OIC). We are indebted to C. Törn for excellent technical assistance.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (MICA) alleles 5 and 5. 1 have been reported to be associated with T1DM in Caucasians. Sweden ranks third in the world for T1DM incidence. In Sweden, the Linköping region indicates the highest incidence for T1DM. In this study, we analyzed whether antibodies against CBV are increased in DR3, DR4, MICA5, or MICA5.1 positive patients from Linköping (n = 46) and from Swedish population as a whole (n = 298) between the age of 0 and 15 years old. There was no difference in the frequency of antibodies to CBV in patients compared with controls in Linköping (26% vs 23%) or in all of Sweden (26% vs 21%). However, CBV antibodies were increased in DR3, DR3-DR4 (heterozygous), DR3-MICA5.1, and DR3-DR4-MICA5.1 positive compared with DR3, DR3-DR4, DR3-MICA5.1, and DR3-DR4-MICA5.1 negative patients in Linköping (p < 0.05 for all), but not in Swedish population as a whole. Thus, our study suggests that in addition to DR3, MICA5.1 has an influence on the immune response to CBV infection in patients from Link̈ping.
AB - Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (MICA) alleles 5 and 5. 1 have been reported to be associated with T1DM in Caucasians. Sweden ranks third in the world for T1DM incidence. In Sweden, the Linköping region indicates the highest incidence for T1DM. In this study, we analyzed whether antibodies against CBV are increased in DR3, DR4, MICA5, or MICA5.1 positive patients from Linköping (n = 46) and from Swedish population as a whole (n = 298) between the age of 0 and 15 years old. There was no difference in the frequency of antibodies to CBV in patients compared with controls in Linköping (26% vs 23%) or in all of Sweden (26% vs 21%). However, CBV antibodies were increased in DR3, DR3-DR4 (heterozygous), DR3-MICA5.1, and DR3-DR4-MICA5.1 positive compared with DR3, DR3-DR4, DR3-MICA5.1, and DR3-DR4-MICA5.1 negative patients in Linköping (p < 0.05 for all), but not in Swedish population as a whole. Thus, our study suggests that in addition to DR3, MICA5.1 has an influence on the immune response to CBV infection in patients from Link̈ping.
KW - CBV
KW - HLA-DQ
KW - HLA-DR
KW - MICA
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=0041833338&partnerID=8YFLogxK
U2 - 10.1016/S0198-8859(03)00149-6
DO - 10.1016/S0198-8859(03)00149-6
M3 - Article
C2 - 12941542
AN - SCOPUS:0041833338
SN - 0198-8859
VL - 64
SP - 874
EP - 879
JO - Human Immunology
JF - Human Immunology
IS - 9
ER -
