TY - JOUR
T1 - Current Situation of Solid Organ Transplantation from HIV-Positive Donors to HIV-Positive Recipients in Europe. The Spanish Perspective
AU - Miro, Jose M
AU - Amondarain, Nerea L
AU - Serrano, Lucia
AU - Salmanton-Garcia, Jon
AU - Manzardo, Christian
AU - Malano-Barletta, Daniela
AU - Paredes-Zapata, David
AU - Guerra-Maio, Antonio
AU - Stahl, Jean-Paul
AU - Subirana, Marta
AU - Ruiz, Pablo
AU - Fondevila, Constantino
AU - Cofán, Federic
AU - González, Angela
AU - Musquera, Mireia
AU - Mahillo, Beatriz
AU - Rosa, Gloria de la
AU - Marazuela, Rosario
AU - Rimola, Antonio
AU - Moreno, Asuncion
AU - Spanish LT/KT in HIV-Infected Patients Working Group investigators
AU - European Union of Medical Specialists Section of Infectious Diseases (UEMS-ID) investigators
A2 - Laivacuma, Sniedze
A2 - Zeltiņa, Indra
N1 - S.Laivacumai un I.Zeltiņai datubāzes Pubmed publikācijā ir norādīta tikai afiliācijas valsts: Latvija. Publikācijas pilnais teksts žurnāla mājaslapā nav pieejams.
Publikācija ir redzama S.Laivacumas un I.Zeltiņas Web Of Science profilos.
Copyright © 2025 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
PY - 2025/9/2
Y1 - 2025/9/2
N2 - OBJECTIVES: There is limited information on the use of organs from HIV-positive donors (HIV D+) for HIV-positive recipients (HIV R+) in Europe. In some countries the use of HIV D+ organs is prohibited by law. This study aimed to assess the attitudes of Spanish kidney and liver transplant (KT/LT) teams towards HIV D+/R+ KT/LT through a nationwide survey, and to evaluate the current situation across Europe regarding legislation and reported cases.METHODS: In 2018 and 2019, two surveys were conducted across Spain's 24 LT and 39 KT centres, respectively. Specialists in HIV/infectious diseases, nephrology/hepatology, urology/liver surgery and transplant coordination completed a questionnaire, with responses analysed by speciality. We also consulted European representatives on national legal frameworks regarding HIV D+/R+ and conducted a narrative review of published cases (2000-2025).RESULTS: The Spanish survey was answered by at least one member of all Spanish LT and KT teams (63/63, 100%). Most specialists who responded to the survey (167/252; 66%) supported using organs from HIV D+ virologically suppressed (VS) on ART, high-risk and serodiscordant couples, but not from non-VS HIV D+, for HIV R+. All respondents endorsed implementing a dedicated consent form, and a majority expressed willingness to participate in an HIV D+/R+ trial. No major differences were observed between LT and KT teams. At the European level, the use of organs from HIV D+ was permitted, prohibited or unregulated in 6 (17%), 11 (31.5%) and 18 (51.5%) countries, respectively. Ten HIV D+/R+ transplants (six kidneys and four livers) have been published, with good one-year outcomes.CONCLUSIONS: The surveyed Spanish specialists would agree on using organs from VS HIV D+ for HIV D+/R+ transplants. This procedure is only legally allowed in very few European countries. These results should promote changes in donor laws across Europe.
AB - OBJECTIVES: There is limited information on the use of organs from HIV-positive donors (HIV D+) for HIV-positive recipients (HIV R+) in Europe. In some countries the use of HIV D+ organs is prohibited by law. This study aimed to assess the attitudes of Spanish kidney and liver transplant (KT/LT) teams towards HIV D+/R+ KT/LT through a nationwide survey, and to evaluate the current situation across Europe regarding legislation and reported cases.METHODS: In 2018 and 2019, two surveys were conducted across Spain's 24 LT and 39 KT centres, respectively. Specialists in HIV/infectious diseases, nephrology/hepatology, urology/liver surgery and transplant coordination completed a questionnaire, with responses analysed by speciality. We also consulted European representatives on national legal frameworks regarding HIV D+/R+ and conducted a narrative review of published cases (2000-2025).RESULTS: The Spanish survey was answered by at least one member of all Spanish LT and KT teams (63/63, 100%). Most specialists who responded to the survey (167/252; 66%) supported using organs from HIV D+ virologically suppressed (VS) on ART, high-risk and serodiscordant couples, but not from non-VS HIV D+, for HIV R+. All respondents endorsed implementing a dedicated consent form, and a majority expressed willingness to participate in an HIV D+/R+ trial. No major differences were observed between LT and KT teams. At the European level, the use of organs from HIV D+ was permitted, prohibited or unregulated in 6 (17%), 11 (31.5%) and 18 (51.5%) countries, respectively. Ten HIV D+/R+ transplants (six kidneys and four livers) have been published, with good one-year outcomes.CONCLUSIONS: The surveyed Spanish specialists would agree on using organs from VS HIV D+ for HIV D+/R+ transplants. This procedure is only legally allowed in very few European countries. These results should promote changes in donor laws across Europe.
UR - https://pubmed.ncbi.nlm.nih.gov/40907699/
UR - https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:40907699
U2 - 10.1016/j.cmi.2025.08.025
DO - 10.1016/j.cmi.2025.08.025
M3 - Article
C2 - 40907699
SN - 1198-743X
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
ER -
