Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry

Baiba Svalbe, Solveiga Grinberga, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Eduards Sevostjanovs, Maija Dambrova, Liga Zvejniece

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

MK-801, a N-methyl-D-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1].

Original languageEnglish
Article number104623
JournalData in Brief
Volume27
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Bioavailability
  • i.p. and s.c. administration route
  • Mice
  • MK-801
  • UPLC-MS/MS

Field of Science

  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint Dive into the research topics of 'Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry'. Together they form a unique fingerprint.

Cite this