Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

Silvia Rosina; Ana I Rebollo-Giménez; Letizia Tarantola; Angela Pistorio; Yulia Vyzhga; Yasser El Miedany; Hala M Lotfy; Hend Abu-Shady; Mervat Eissa; Naglaa S Osman; Waleed Hassan; Marwa Y Mahgoub; Nermeen A Fouad; Doaa M Mosa; Yasmin Adel; Sheren E M Mohamed; Ahmed R Radwan; Mohamed H Abu-Zaid; Samar A A Tabra; Radwa H Shalaby; Samah I Nasef; Raju Khubchandani; Archana Khan; Naziya P Maldar; Seza Ozen; Yagmur Bayindir; Motasem Alsuweiti; Raed Alzyoud; Hiba Almaaitah; Soamarat Vilaiyuk; Butsabong Lerkvaleekul; Ekaterina Alexeeva; Tatyana Dvoryakovskaya; Ivan Kriulin; Claudia Bracaglia; Manuela Pardeo; Fabrizio De Benedetti; Francesco Licciardi; Davide Montin; Francesca Robasto; Francesca Minoia; Giovanni Filocamo; Martina Rossano; Gabriele Simonini; Edoardo Marrani; Sarah Abu-Rumeileh; Mikhail M Kostik; Konstantin E Belozerov; Priyankar Pal; Jigna N Bathia; María M Katsicas; Giselle Villarreal; Achille Marino; Stefania Costi; Flavio Sztajnbok; Rodrigo M Silva; Maria C Maggio; Dalia H El-Ghoneimy; Rasha El Owaidy; Adele Civino; Federico Diomeda; Sulaiman M Al-Mayouf; Fuad Al-Sofyani; Zane Dāvidsone; Elisa Patrone; Claudia Saad-Magalhães; Alessandro Consolaro; Angelo Ravelli

doi:10.1002/art.42865

Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

Silvia Rosina, Ana I Rebollo-Giménez, Letizia Tarantola, Angela Pistorio, Yulia Vyzhga, Yasser El Miedany, Hala M Lotfy, Hend Abu-Shady, Mervat Eissa, Naglaa S Osman, Waleed Hassan, Marwa Y Mahgoub, Nermeen A Fouad, Doaa M Mosa, Yasmin Adel, Sheren E M Mohamed, Ahmed R Radwan, Mohamed H Abu-Zaid, Samar A A Tabra, Radwa H ShalabySamah I Nasef, Raju Khubchandani, Archana Khan, Naziya P Maldar, Seza Ozen, Yagmur Bayindir, Motasem Alsuweiti, Raed Alzyoud, Hiba Almaaitah, Soamarat Vilaiyuk, Butsabong Lerkvaleekul, Ekaterina Alexeeva, Tatyana Dvoryakovskaya, Ivan Kriulin, Claudia Bracaglia, Manuela Pardeo, Fabrizio De Benedetti, Francesco Licciardi, Davide Montin, Francesca Robasto, Francesca Minoia, Giovanni Filocamo, Martina Rossano, Gabriele Simonini, Edoardo Marrani, Sarah Abu-Rumeileh, Mikhail M Kostik, Konstantin E Belozerov, Priyankar Pal, Jigna N Bathia, María M Katsicas, Giselle Villarreal, Achille Marino, Stefania Costi, Flavio Sztajnbok, Rodrigo M Silva, Maria C Maggio, Dalia H El-Ghoneimy, Rasha El Owaidy, Adele Civino, Federico Diomeda, Sulaiman M Al-Mayouf, Fuad Al-Sofyani, Zane Dāvidsone, Elisa Patrone, Claudia Saad-Magalhães, Alessandro Consolaro, Angelo Ravelli (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

3 Downloads (Pure)

Abstract

OBJECTIVE: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist.

METHODS: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability.

RESULTS: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome.

CONCLUSION: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.

Original language	English
Pages (from-to)	1446-1454
Number of pages	9
Journal	Arthritis & Rheumatology
Volume	76
Issue number	9
DOIs	https://doi.org/10.1002/art.42865
Publication status	Published - Sept 2024
Externally published	Yes

Keywords*

Adolescent
Child
Child, Preschool
Female
Humans
Male
Arthritis, Juvenile/physiopathology
Cohort Studies
ROC Curve
Severity of Illness Index

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1002/art.42865Licence: CC BY-NC-ND

Deﬁning Criteria for DiseaseFinal published version, 638 KBLicence: CC BY-NC-ND

Cite this

Rosina, S., Rebollo-Giménez, A. I., Tarantola, L., Pistorio, A., Vyzhga, Y., El Miedany, Y., Lotfy, H. M., Abu-Shady, H., Eissa, M., Osman, N. S., Hassan, W., Mahgoub, M. Y., Fouad, N. A., Mosa, D. M., Adel, Y., Mohamed, S. E. M., Radwan, A. R., Abu-Zaid, M. H., Tabra, S. A. A., ... Ravelli, A. (2024). Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score. Arthritis & Rheumatology, 76(9), 1446-1454. https://doi.org/10.1002/art.42865

@article{d53da5feeb334ec7b087230f68711d2c,

title = "Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score",

abstract = "OBJECTIVE: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist.METHODS: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability.RESULTS: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome.CONCLUSION: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.",

keywords = "Adolescent, Child, Child, Preschool, Female, Humans, Male, Arthritis, Juvenile/physiopathology, Cohort Studies, ROC Curve, Severity of Illness Index",

author = "Silvia Rosina and Rebollo-Gim{\'e}nez, {Ana I} and Letizia Tarantola and Angela Pistorio and Yulia Vyzhga and {El Miedany}, Yasser and Lotfy, {Hala M} and Hend Abu-Shady and Mervat Eissa and Osman, {Naglaa S} and Waleed Hassan and Mahgoub, {Marwa Y} and Fouad, {Nermeen A} and Mosa, {Doaa M} and Yasmin Adel and Mohamed, {Sheren E M} and Radwan, {Ahmed R} and Abu-Zaid, {Mohamed H} and Tabra, {Samar A A} and Shalaby, {Radwa H} and Nasef, {Samah I} and Raju Khubchandani and Archana Khan and Maldar, {Naziya P} and Seza Ozen and Yagmur Bayindir and Motasem Alsuweiti and Raed Alzyoud and Hiba Almaaitah and Soamarat Vilaiyuk and Butsabong Lerkvaleekul and Ekaterina Alexeeva and Tatyana Dvoryakovskaya and Ivan Kriulin and Claudia Bracaglia and Manuela Pardeo and {De Benedetti}, Fabrizio and Francesco Licciardi and Davide Montin and Francesca Robasto and Francesca Minoia and Giovanni Filocamo and Martina Rossano and Gabriele Simonini and Edoardo Marrani and Sarah Abu-Rumeileh and Kostik, {Mikhail M} and Belozerov, {Konstantin E} and Priyankar Pal and Bathia, {Jigna N} and Katsicas, {Mar{\'i}a M} and Giselle Villarreal and Achille Marino and Stefania Costi and Flavio Sztajnbok and Silva, {Rodrigo M} and Maggio, {Maria C} and El-Ghoneimy, {Dalia H} and {El Owaidy}, Rasha and Adele Civino and Federico Diomeda and Al-Mayouf, {Sulaiman M} and Fuad Al-Sofyani and Zane Dāvidsone and Elisa Patrone and Claudia Saad-Magalh{\~a}es and Alessandro Consolaro and Angelo Ravelli",

note = "{\textcopyright} 2024 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.",

year = "2024",

month = sep,

doi = "10.1002/art.42865",

language = "English",

volume = "76",

pages = "1446--1454",

journal = "Arthritis & Rheumatology",

issn = "2326-5191",

publisher = "John Wiley and Sons Ltd",

number = "9",

}

Rosina, S, Rebollo-Giménez, AI, Tarantola, L, Pistorio, A, Vyzhga, Y, El Miedany, Y, Lotfy, HM, Abu-Shady, H, Eissa, M, Osman, NS, Hassan, W, Mahgoub, MY, Fouad, NA, Mosa, DM, Adel, Y, Mohamed, SEM, Radwan, AR, Abu-Zaid, MH, Tabra, SAA, Shalaby, RH, Nasef, SI, Khubchandani, R, Khan, A, Maldar, NP, Ozen, S, Bayindir, Y, Alsuweiti, M, Alzyoud, R, Almaaitah, H, Vilaiyuk, S, Lerkvaleekul, B, Alexeeva, E, Dvoryakovskaya, T, Kriulin, I, Bracaglia, C, Pardeo, M, De Benedetti, F, Licciardi, F, Montin, D, Robasto, F, Minoia, F, Filocamo, G, Rossano, M, Simonini, G, Marrani, E, Abu-Rumeileh, S, Kostik, MM, Belozerov, KE, Pal, P, Bathia, JN, Katsicas, MM, Villarreal, G, Marino, A, Costi, S, Sztajnbok, F, Silva, RM, Maggio, MC, El-Ghoneimy, DH, El Owaidy, R, Civino, A, Diomeda, F, Al-Mayouf, SM, Al-Sofyani, F, Dāvidsone, Z, Patrone, E, Saad-Magalhães, C, Consolaro, A & Ravelli, A 2024, 'Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score', Arthritis & Rheumatology, vol. 76, no. 9, pp. 1446-1454. https://doi.org/10.1002/art.42865

TY - JOUR

T1 - Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

AU - Rosina, Silvia

AU - Rebollo-Giménez, Ana I

AU - Tarantola, Letizia

AU - Pistorio, Angela

AU - Vyzhga, Yulia

AU - El Miedany, Yasser

AU - Lotfy, Hala M

AU - Abu-Shady, Hend

AU - Eissa, Mervat

AU - Osman, Naglaa S

AU - Hassan, Waleed

AU - Mahgoub, Marwa Y

AU - Fouad, Nermeen A

AU - Mosa, Doaa M

AU - Adel, Yasmin

AU - Mohamed, Sheren E M

AU - Radwan, Ahmed R

AU - Abu-Zaid, Mohamed H

AU - Tabra, Samar A A

AU - Shalaby, Radwa H

AU - Nasef, Samah I

AU - Khubchandani, Raju

AU - Khan, Archana

AU - Maldar, Naziya P

AU - Ozen, Seza

AU - Bayindir, Yagmur

AU - Alsuweiti, Motasem

AU - Alzyoud, Raed

AU - Almaaitah, Hiba

AU - Vilaiyuk, Soamarat

AU - Lerkvaleekul, Butsabong

AU - Alexeeva, Ekaterina

AU - Dvoryakovskaya, Tatyana

AU - Kriulin, Ivan

AU - Bracaglia, Claudia

AU - Pardeo, Manuela

AU - De Benedetti, Fabrizio

AU - Licciardi, Francesco

AU - Montin, Davide

AU - Robasto, Francesca

AU - Minoia, Francesca

AU - Filocamo, Giovanni

AU - Rossano, Martina

AU - Simonini, Gabriele

AU - Marrani, Edoardo

AU - Abu-Rumeileh, Sarah

AU - Kostik, Mikhail M

AU - Belozerov, Konstantin E

AU - Pal, Priyankar

AU - Bathia, Jigna N

AU - Katsicas, María M

AU - Villarreal, Giselle

AU - Marino, Achille

AU - Costi, Stefania

AU - Sztajnbok, Flavio

AU - Silva, Rodrigo M

AU - Maggio, Maria C

AU - El-Ghoneimy, Dalia H

AU - El Owaidy, Rasha

AU - Civino, Adele

AU - Diomeda, Federico

AU - Al-Mayouf, Sulaiman M

AU - Al-Sofyani, Fuad

AU - Dāvidsone, Zane

AU - Patrone, Elisa

AU - Saad-Magalhães, Claudia

AU - Consolaro, Alessandro

AU - Ravelli, Angelo

PY - 2024/9

Y1 - 2024/9

N2 - OBJECTIVE: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist.METHODS: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability.RESULTS: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome.CONCLUSION: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.

AB - OBJECTIVE: Our objective was to develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with systemic juvenile idiopathic arthritis, based on subjective disease state assessment by the treating pediatric rheumatologist.METHODS: The cutoff definition cohort was composed of 400 patients enrolled at 30 pediatric rheumatology centers in 11 countries. Using the subjective physician rating as an external criterion, six methods were applied to identify the cutoffs: mapping, calculation of percentiles of cumulative score distribution, the Youden index, 90% specificity, maximum agreement, and receiver operating characteristic curve analysis. Sixty percent of the patients were assigned to the definition cohort, and 40% were assigned to the validation cohort. Cutoff validation was conducted by assessing discriminative ability.RESULTS: The sJADAS10 cutoffs that separated ID from MDA, MDA from MoDA, and MoDA from HDA were ≤2.9, ≤10, and >20.6, respectively. The cutoffs discriminated strongly among different levels of pain, between patients with and without morning stiffness, and among patients whose parents judged their disease status as remission or persistent activity or flare or were satisfied or not satisfied with current illness outcome.CONCLUSION: The sJADAS cutoffs revealed good metrologic properties in both definition and validation cohorts and are therefore suitable for use in clinical trials and routine practice.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Male

KW - Arthritis, Juvenile/physiopathology

KW - Cohort Studies

KW - ROC Curve

KW - Severity of Illness Index

U2 - 10.1002/art.42865

DO - 10.1002/art.42865

M3 - Article

C2 - 38682570

SN - 2326-5191

VL - 76

SP - 1446

EP - 1454

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

IS - 9

ER -

Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

Abstract

Keywords*

Field of Science*

Publication Type*

Access to Document

Fingerprint

Cite this