TY - JOUR
T1 - Design, Fabrication, and Application of Mini-Scaffolds for Cell Components in Tissue Engineering
AU - Mironov, Vladimir A.
AU - Senatov, Fedor S.
AU - Koudan, Elizaveta V.
AU - Pereira, Frederico D.A.S.
AU - Kasyanov, Vladimir A.
AU - Granjeiro, Jose Mauro
AU - Baptista, Leandra Santos
N1 - Funding Information:
This research was funded by the Ministry of Science and Higher Education of the Russian Federation under the strategic academic Not acceptable leadership program “Priority 2030”.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - The concept of “lockyballs” or interlockable mini-scaffolds fabricated by two-photon polymerization from biodegradable polymers for the encagement of tissue spheroids and their delivery into the desired location in the human body has been recently introduced. In order to improve control of delivery, positioning, and assembly of mini-scaffolds with tissue spheroids inside, they must be functionalized. This review describes the design, fabrication, and functionalization of mini-scaffolds as well as perspectives on their application in tissue engineering for precisely controlled cell and mini-tissue delivery and patterning. The development of functionalized mini-scaffolds advances the original concept of “lockyballs” and opens exciting new prospectives for mini-scaffolds’ applications in tissue engineering and regenerative medicine and their eventual clinical translation.
AB - The concept of “lockyballs” or interlockable mini-scaffolds fabricated by two-photon polymerization from biodegradable polymers for the encagement of tissue spheroids and their delivery into the desired location in the human body has been recently introduced. In order to improve control of delivery, positioning, and assembly of mini-scaffolds with tissue spheroids inside, they must be functionalized. This review describes the design, fabrication, and functionalization of mini-scaffolds as well as perspectives on their application in tissue engineering for precisely controlled cell and mini-tissue delivery and patterning. The development of functionalized mini-scaffolds advances the original concept of “lockyballs” and opens exciting new prospectives for mini-scaffolds’ applications in tissue engineering and regenerative medicine and their eventual clinical translation.
KW - functionalization
KW - mini-scaffolds
KW - synergistic approach
KW - tissue spheroids
UR - http://www.scopus.com/inward/record.url?scp=85143636177&partnerID=8YFLogxK
U2 - 10.3390/polym14235068
DO - 10.3390/polym14235068
M3 - Review article
AN - SCOPUS:85143636177
SN - 2073-4360
VL - 14
JO - Polymers
JF - Polymers
IS - 23
M1 - 5068
ER -
