Design of Liposomes Carrying Helixcomplex Snail Mucus: Preliminary Studies

Andrea Alogna (Coresponding Author), Valentina Gentili, Claudio Trapella, Supandeep Singh Hallan, Maddalena Sguizzato, Giovanni Strazzabosco, Mercedes Fernández, Rita Cortesi (Coresponding Author), Roberta Rizzo, Daria Bortolotti

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In recent decades liposomes have been used in different field thanks to their ability to act as a vehicle for a wide range of biomolecules, their great versatility and their easy production. The aim of this study was to evaluate liposomes as a vehicle for the actives present in the HelixComplex (HC) snail mucus for topical delivery. Liposomes composed of a mixture of phosphatidylcholine, cholesterol and octadecylamine were prepared with and without HC (empty liposomes) and their biological efficacy was tested by evaluating cell viability and migration. HC-loaded liposomes (LHC) were stable throughout 60 days of observation, and showed interesting effects on wound healing reconstitution. In particular, we observed that 25 µg/mL LHC were already able to induce a higher cell monolayer reconstitution in comparison to the untreated samples and HC treated samples after only 4 h (28% versus 10% and 7%, p = 0.03 and p= 0.003, respectively). The effect was more evident at 24 h in comparison with the untreated control (54% versus 21.2% and 41.6%, p = 0.006 and p = NS, respectively). These results represent a preliminary, but promising, novelty in the delivery strategy of the actives present in the HelixComplex mucus.

Original languageEnglish
Article number4709
JournalMolecules
Volume26
Issue number16
DOIs
Publication statusPublished - 2 Aug 2021
Externally publishedYes

Keywords*

  • Drug delivery
  • HelixComplex
  • Liposomes
  • MTT test
  • Slime mucus

Field of Science*

  • 1.4 Chemical sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Design of Liposomes Carrying Helixcomplex Snail Mucus: Preliminary Studies'. Together they form a unique fingerprint.

Cite this