Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip

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Abstract

Background: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalOpen Dermatology Journal
Volume11
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • Cleft
  • HGF
  • IGF-1
  • IGF-1R
  • Lip mucosa
  • Orofacial defects
  • TGF-β1

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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