Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability

Kritika Sharma; Supandeep Singh Hallan; Bharat Lal; Ankur Bhardwaj; Neeraj Mishra

doi:10.3109/21691401.2015.1041637

Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability

Kritika Sharma, Supandeep Singh Hallan, Bharat Lal, Ankur Bhardwaj, Neeraj Mishra

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.

Original language	English
Pages (from-to)	1448-1456
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	44
Issue number	6
DOIs	https://doi.org/10.3109/21691401.2015.1041637
Publication status	Published - Aug 2016
Externally published	Yes

Keywords*

floating spheroids
hyperlipidemia
nanostructured lipid carriers (NLCs)
oral bioavailability

Field of Science*

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3109/21691401.2015.1041637

Cite this

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title = "Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability",

abstract = "Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.",

keywords = "floating spheroids, hyperlipidemia, nanostructured lipid carriers (NLCs), oral bioavailability",

author = "Kritika Sharma and Hallan, {Supandeep Singh} and Bharat Lal and Ankur Bhardwaj and Neeraj Mishra",

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year = "2016",

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doi = "10.3109/21691401.2015.1041637",

language = "English",

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journal = "Artificial Cells, Nanomedicine and Biotechnology",

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TY - JOUR

T1 - Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability

AU - Sharma, Kritika

AU - Hallan, Supandeep Singh

AU - Lal, Bharat

AU - Bhardwaj, Ankur

AU - Mishra, Neeraj

PY - 2016/8

Y1 - 2016/8

N2 - Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.

AB - Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.

KW - floating spheroids

KW - hyperlipidemia

KW - nanostructured lipid carriers (NLCs)

KW - oral bioavailability

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U2 - 10.3109/21691401.2015.1041637

DO - 10.3109/21691401.2015.1041637

M3 - Article

C2 - 25960179

AN - SCOPUS:84982949224

SN - 2169-1401

VL - 44

SP - 1448

EP - 1456

JO - Artificial Cells, Nanomedicine and Biotechnology

JF - Artificial Cells, Nanomedicine and Biotechnology

IS - 6

ER -

Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability

Abstract

Keywords*

Field of Science*

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