Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability

Kritika Sharma, Supandeep Singh Hallan, Bharat Lal, Ankur Bhardwaj, Neeraj Mishra

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.

Original languageEnglish
Pages (from-to)1448-1456
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number6
DOIs
Publication statusPublished - Aug 2016
Externally publishedYes

Keywords*

  • floating spheroids
  • hyperlipidemia
  • nanostructured lipid carriers (NLCs)
  • oral bioavailability

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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