Abstract
Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.
| Original language | English |
|---|---|
| Pages (from-to) | 1448-1456 |
| Journal | Artificial Cells, Nanomedicine and Biotechnology |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Aug 2016 |
| Externally published | Yes |
Keywords*
- floating spheroids
- hyperlipidemia
- nanostructured lipid carriers (NLCs)
- oral bioavailability
Field of Science*
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
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