Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Supandeep Singh Hallan, Nidhi, Veerpal Kaur, Vikas Jain, Neeraj Mishra

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The present study aimed to develop an improved oral delivery system for low-molecular-weight heparin (LMWH), novel polymer lipid hybrid nanoparticles were developed. LMWH loaded chitosan polymer lipid hybrid nanoparticles (LMWH-CS-PLNs) were developed using double emulsification and solvent evaporation method. The performance of developed formulations was evaluated by using in vitro and in vivo behavior, such as drug release studies, in vitro permeation study, in vivo venous thrombolytic study, in vitro uptake studies by using intestinal epithelium resembling Caco-2 cell lines. The new CS-PLNs might provide an effective strategy for oral delivery of LMWH with improved encapsulation efficiency as compared to CS-NPs and SA-LNPs.

Original languageEnglish
Pages (from-to)1631-1639
Number of pages9
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume45
Issue number8
DOIs
Publication statusPublished - 17 Nov 2017
Externally publishedYes

Keywords*

  • chitosan nanoparticles
  • hydrophilic
  • Lipid nanoparticles
  • low molecular weight heparin
  • polymer lipid hybrid nanoparticles

Field of Science*

  • 3.1 Basic medicine
  • 3.4 Medical biotechnology

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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