Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Supandeep Singh Hallan; Nidhi; Veerpal Kaur; Vikas Jain; Neeraj Mishra

doi:10.1080/21691401.2016.1276920

Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Supandeep Singh Hallan, Nidhi, Veerpal Kaur, Vikas Jain, Neeraj Mishra

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The present study aimed to develop an improved oral delivery system for low-molecular-weight heparin (LMWH), novel polymer lipid hybrid nanoparticles were developed. LMWH loaded chitosan polymer lipid hybrid nanoparticles (LMWH-CS-PLNs) were developed using double emulsification and solvent evaporation method. The performance of developed formulations was evaluated by using in vitro and in vivo behavior, such as drug release studies, in vitro permeation study, in vivo venous thrombolytic study, in vitro uptake studies by using intestinal epithelium resembling Caco-2 cell lines. The new CS-PLNs might provide an effective strategy for oral delivery of LMWH with improved encapsulation efficiency as compared to CS-NPs and SA-LNPs.

Original language	English
Pages (from-to)	1631-1639
Number of pages	9
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	45
Issue number	8
DOIs	https://doi.org/10.1080/21691401.2016.1276920
Publication status	Published - 17 Nov 2017
Externally published	Yes

Keywords*

chitosan nanoparticles
hydrophilic
Lipid nanoparticles
low molecular weight heparin
polymer lipid hybrid nanoparticles

Field of Science*

3.1 Basic medicine
3.4 Medical biotechnology

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1080/21691401.2016.1276920

Cite this

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title = "Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH",

abstract = "The present study aimed to develop an improved oral delivery system for low-molecular-weight heparin (LMWH), novel polymer lipid hybrid nanoparticles were developed. LMWH loaded chitosan polymer lipid hybrid nanoparticles (LMWH-CS-PLNs) were developed using double emulsification and solvent evaporation method. The performance of developed formulations was evaluated by using in vitro and in vivo behavior, such as drug release studies, in vitro permeation study, in vivo venous thrombolytic study, in vitro uptake studies by using intestinal epithelium resembling Caco-2 cell lines. The new CS-PLNs might provide an effective strategy for oral delivery of LMWH with improved encapsulation efficiency as compared to CS-NPs and SA-LNPs.",

keywords = "chitosan nanoparticles, hydrophilic, Lipid nanoparticles, low molecular weight heparin, polymer lipid hybrid nanoparticles",

author = "Hallan, {Supandeep Singh} and Nidhi and Veerpal Kaur and Vikas Jain and Neeraj Mishra",

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doi = "10.1080/21691401.2016.1276920",

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T1 - Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

AU - Hallan, Supandeep Singh

AU - Nidhi,

AU - Kaur, Veerpal

AU - Jain, Vikas

AU - Mishra, Neeraj

PY - 2017/11/17

Y1 - 2017/11/17

N2 - The present study aimed to develop an improved oral delivery system for low-molecular-weight heparin (LMWH), novel polymer lipid hybrid nanoparticles were developed. LMWH loaded chitosan polymer lipid hybrid nanoparticles (LMWH-CS-PLNs) were developed using double emulsification and solvent evaporation method. The performance of developed formulations was evaluated by using in vitro and in vivo behavior, such as drug release studies, in vitro permeation study, in vivo venous thrombolytic study, in vitro uptake studies by using intestinal epithelium resembling Caco-2 cell lines. The new CS-PLNs might provide an effective strategy for oral delivery of LMWH with improved encapsulation efficiency as compared to CS-NPs and SA-LNPs.

AB - The present study aimed to develop an improved oral delivery system for low-molecular-weight heparin (LMWH), novel polymer lipid hybrid nanoparticles were developed. LMWH loaded chitosan polymer lipid hybrid nanoparticles (LMWH-CS-PLNs) were developed using double emulsification and solvent evaporation method. The performance of developed formulations was evaluated by using in vitro and in vivo behavior, such as drug release studies, in vitro permeation study, in vivo venous thrombolytic study, in vitro uptake studies by using intestinal epithelium resembling Caco-2 cell lines. The new CS-PLNs might provide an effective strategy for oral delivery of LMWH with improved encapsulation efficiency as compared to CS-NPs and SA-LNPs.

KW - chitosan nanoparticles

KW - hydrophilic

KW - Lipid nanoparticles

KW - low molecular weight heparin

KW - polymer lipid hybrid nanoparticles

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U2 - 10.1080/21691401.2016.1276920

DO - 10.1080/21691401.2016.1276920

M3 - Article

C2 - 28071140

AN - SCOPUS:85009223192

SN - 2169-1401

VL - 45

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JO - Artificial Cells, Nanomedicine and Biotechnology

JF - Artificial Cells, Nanomedicine and Biotechnology

IS - 8

ER -

Development and characterization of polymer lipid hybrid nanoparticles for oral delivery of LMWH

Abstract

Keywords*

Field of Science*

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