Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications

Alizadeh Kimia, Yasaman Dezvare, Shirin Kamyab, Jhaleh Amirian (Coresponding Author), Agnese Brangule, Dace Bandere

Research output: Contribution to journalArticlepeer-review


In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO2 NPs). CRG-CeO2-0.5 and CRG-CeO2-1 composites were prepared by compositing CeO2 to CRG + CeO2 at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO2 nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO2 exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO2 NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO2-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO2 NPs were present in the CRG matrix. Therefore, CRG-CeO2-1 has the potential to be used as a hemostatic agent and wound dressing.
Original languageEnglish
Article number409
Number of pages17
Issue number5
Publication statusPublished - 4 Sept 2023


  • carrageenan (CRG)
  • cerium oxide (CeO2);
  • nanoparticles (NPs)
  • composite
  • Antibacterial properties
  • hemostatic effect

Field of Science*

  • 1.6 Biological sciences
  • 2.10 Nano-technology
  • 2.5 Materials engineering
  • 2.11 Other engineering and technologies

Publication Type*

  • 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)


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