Development of enteric-coated microspheres of embelin for their beneficial pharmacological potential in ulcerative colitis

Nidhi, Ankita Dadwal, Supandeep Singh Hallan, Saurabh Sharma, Neeraj Mishra

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The aim of the present study is to develop embelin-loaded enteric-coated microspheres and investigate their pharmacological potential in acetic acid induced ulcerative colitis. The optimized formulation of embelin-loaded microspheres has shown significant sustained release of embelin. Further this formulation significantly reduced the ulcer activity score and oxidative stress, and attenuated the inflammatory changes. Thus it may be concluded that embelin-loaded enteric-coated microspheres have shown delayed release capacity than plain embelin and exerts colon ulcer protective effect in rats.

Original languageEnglish
Pages (from-to)1092-1100
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume45
Issue number6
DOIs
Publication statusPublished - 18 Aug 2017
Externally publishedYes

Keywords*

  • Colon
  • Eudragit S 100
  • multiparticulate carrier
  • pH dependent
  • time dependent

Field of Science*

  • 3.1 Basic medicine
  • 3.4 Medical biotechnology

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Development of enteric-coated microspheres of embelin for their beneficial pharmacological potential in ulcerative colitis'. Together they form a unique fingerprint.

Cite this