Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand

Linda Bara; Jeļena Eglīte; Vinita Cauce; Elvīra Hagina; Peteris Ošs; Sandra Gintere; Ludmila Vīksna; Angelika Krūmiņa

Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand

Linda Bara (Corresponding Author), Jeļena Eglīte, Vinita Cauce, Elvīra Hagina, Peteris Ošs, Sandra Gintere, Ludmila Vīksna, Angelika Krūmiņa

Research output: Contribution to journal › Article › peer-review

Abstract

Sepsis is a condition with high mortality rates and its diagnosis remains a challenge. Therefore, a new diagnostic biomarker
or combinations of biomarkers for diagnosis of sepsis should be developed. In total, 80 patients who were suspected of
having sepsis were followed up for 7days. Quick Sepsis-related Organ Failure Assessment (qSOFA) scores were calculated
day 1 and day 7; four biomarkers (intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen
activator inhibitor-1 and soluble Fas ligand) results were evaluated the same. In 7 days in sepsis patients, blood serum
concentrations of biomarker intercellular adhesion molecule-1 (ICAM-1) increased, p=0.022.

Original language	English
Pages (from-to)	1361-1367
Number of pages	7
Journal	Clinical Practice
Volume	16
Issue number	S1
Publication status	Published - 2019

Keywords*

sepsis
intercellular adhesion molecule-1
macrophage migration inhibitory factor
plasminogen activator inhibitor-1

Field of Science*

3.2 Clinical medicine

Publication Type*

1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)

Access to Document

https://www.openaccessjournals.com/articles/development-of-sepsis-in-relation-to-serum-biomarkers-concentration-like-intercellular-adhesion-molecule1-macrophage-mig.pdf

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Bara, L., Eglīte, J., Cauce, V., Hagina, E., Ošs, P., Gintere, S., Vīksna, L., & Krūmiņa, A. (2019). Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand. Clinical Practice, 16(S1), 1361-1367. https://www.openaccessjournals.com/articles/development-of-sepsis-in-relation-to-serum-biomarkers-concentration-like-intercellular-adhesion-molecule1-macrophage-mig.pdf

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title = "Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand",

abstract = "Sepsis is a condition with high mortality rates and its diagnosis remains a challenge. Therefore, a new diagnostic biomarker or combinations of biomarkers for diagnosis of sepsis should be developed. In total, 80 patients who were suspected of having sepsis were followed up for 7days. Quick Sepsis-related Organ Failure Assessment (qSOFA) scores were calculated day 1 and day 7; four biomarkers (intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand) results were evaluated the same. In 7 days in sepsis patients, blood serum concentrations of biomarker intercellular adhesion molecule-1 (ICAM-1) increased, p=0.022.",

keywords = "sepsis, intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1",

author = "Linda Bara and Jeļena Eglīte and Vinita Cauce and Elvīra Hagina and Peteris O{\v s}s and Sandra Gintere and Ludmila Vīksna and Angelika Krūmiņa",

note = "Clinical Practice (Therapy) journal is an open access, peer reviewed scholarly journal. https://www.openaccessjournals.com/journals/clinical-practice.html",

year = "2019",

language = "English",

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Bara, L, Eglīte, J, Cauce, V , Hagina, E, Ošs, P, Gintere, S , Vīksna, L & Krūmiņa, A 2019, 'Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand', Clinical Practice, vol. 16, no. S1, pp. 1361-1367. <https://www.openaccessjournals.com/articles/development-of-sepsis-in-relation-to-serum-biomarkers-concentration-like-intercellular-adhesion-molecule1-macrophage-mig.pdf>

Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand. / Bara, Linda (Corresponding Author); Eglīte, Jeļena; Cauce, Vinita et al.
In: Clinical Practice, Vol. 16, No. S1, 2019, p. 1361-1367.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Development of sepsis in relation to serum biomarkers concentration like intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand

AU - Bara, Linda

AU - Eglīte, Jeļena

AU - Cauce, Vinita

AU - Hagina, Elvīra

AU - Ošs, Peteris

AU - Gintere, Sandra

AU - Vīksna, Ludmila

AU - Krūmiņa, Angelika

N1 - Clinical Practice (Therapy) journal is an open access, peer reviewed scholarly journal. https://www.openaccessjournals.com/journals/clinical-practice.html

PY - 2019

Y1 - 2019

N2 - Sepsis is a condition with high mortality rates and its diagnosis remains a challenge. Therefore, a new diagnostic biomarker or combinations of biomarkers for diagnosis of sepsis should be developed. In total, 80 patients who were suspected of having sepsis were followed up for 7days. Quick Sepsis-related Organ Failure Assessment (qSOFA) scores were calculated day 1 and day 7; four biomarkers (intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand) results were evaluated the same. In 7 days in sepsis patients, blood serum concentrations of biomarker intercellular adhesion molecule-1 (ICAM-1) increased, p=0.022.

AB - Sepsis is a condition with high mortality rates and its diagnosis remains a challenge. Therefore, a new diagnostic biomarker or combinations of biomarkers for diagnosis of sepsis should be developed. In total, 80 patients who were suspected of having sepsis were followed up for 7days. Quick Sepsis-related Organ Failure Assessment (qSOFA) scores were calculated day 1 and day 7; four biomarkers (intercellular adhesion molecule-1, macrophage migration inhibitory factor, plasminogen activator inhibitor-1 and soluble Fas ligand) results were evaluated the same. In 7 days in sepsis patients, blood serum concentrations of biomarker intercellular adhesion molecule-1 (ICAM-1) increased, p=0.022.

KW - sepsis

KW - intercellular adhesion molecule-1

KW - macrophage migration inhibitory factor

KW - plasminogen activator inhibitor-1

M3 - Article

SN - 2044-9038

VL - 16

SP - 1361

EP - 1367

JO - Clinical Practice

JF - Clinical Practice

IS - S1

ER -