Diagnostic accuracy of multiple biomarkers in predicting the severity of acute pediatric appendicitis in the emergency department

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Abstract

Aim of the study:
Since acute appendicitis (AA) in children can be treated differently according to the severity of the disease, we investigated whether the combined diagnostic model of interleukin-6 (IL-6), leucine-rich alpha-2 glycoprotein 1 (LRG1), neutrophil gelatinase-associated lipocal (NGAL) could distinguish between acute uncomplicated appendicitis (AuA) and acute complicated appendicitis (AcA) and a control group (Ctr).

Materials and Methods:
In this prospective single-centered cohort study, IL-6, LRG1, NGAL in serum were assayed preoperatively. Children aged seven to 18 years old were divided into three groups: AcA, AuA, and Ctr. The Ctr included patients without any suspected inflammatory processes in the respiratory, renal or gastrointestinal tract,. The predictive values of biomarkers were evaluated by receiver operating characteristics curve (ROC) and binary logistic regression models. Two different models were analyzed – AA vs Ctr and AcA vs AuA.

Results:
A total of 153 participants were enrolled, including AcA (n = 52), AuA (n = 45) and Ctr (n = 56). The combined diagnostic model of IL-6, LRG1, NGAL in serum was established by binary logistic regression analysis. The ROC curve showed that combined diagnostic model AA vs Ctr reached a sensitivity of 89.3 %, a specificity of 92.8 % and an area under the curve of 0.96 (95% CI 0.93-0.99, p
Conclusion
The combined diagnostic model of IL-6, LRG1, NGAL at the emergency department (ED) may provide a new approach for the differentiating between AcA and AuA, and for the diagnoses of AA as opposed to other causes of abdominal pain.
Original languageEnglish
Pages397
Number of pages1
Publication statusPublished - 2022
Event23rd Annual Congress of the European Paediatric Surgeons’ Association (EUPSA) - Hilton Hotel Tel Aviv, Telaviv, Israel
Duration: 29 Jun 20222 Jul 2022
Conference number: 23
http://www.eupsa.info/event/23rd-eupsa-annual-congress/
https://www.emedevents.com/c/medical-conferences-2022/23rd-european-paediatric-surgeons-association-eupsa-annual-congress

Congress

Congress23rd Annual Congress of the European Paediatric Surgeons’ Association (EUPSA)
Abbreviated titleEUPSA 2022
Country/TerritoryIsrael
CityTelaviv
Period29/06/222/07/22
Internet address

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)

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