Diagnostic challenges and treatment options for cutaneous T cell pseudolymphoma: A case study with rituximab treatment

Dārta Balode (Coresponding Author), Ludmila Belajeva, Vanessa Ruesseler, Alexander Quaas, Sandra Lejniece

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Rare disease Background: Pseudolymphoma is a rare disorder that can mimic lymphoma both clinically and histologically. It usually af-fects middle-aged females. Since pseudolymphoma is a rare disorder not only is diagnosing the condition dif-ficult, but there is also a lack of standardized treatment guidelines. In the literature, anti-CD20 monoclonal antibody rituximab is described as an effective treatment option. Case Report: 46-year-old female fell ill suddenly with swelling and enlargement of her chin. Multiple skin biopsies were done, which were re-evaluated multiple times as well. Each ended with a new diagnosis for the patient. Finally, in the last revision of biopsy material, pseudolymphoma was confirmed. The patient received multiple courses of cor-ticosteroid treatments – locally and systemically – without long lasting effect. After diagnosis of pseudolym-phoma, the patient was started on intravenous rituximab and this treatment was effective. Conclusions: Cutaneous pseudolymphoma is a diagnostic challenge. Rituximab is a treatment option for refractory pseudo-lymphoma. Since there are no treatment guidelines for pseudolymphoma, more clinical studies are needed to establish best treatment options for these patients. Therefore, each reported clinical case is important.

Original languageEnglish
Article numbere919616
JournalAmerican Journal of Case Reports
Volume21
DOIs
Publication statusPublished - 2020

Keywords

  • Genes, T-Cell Receptor
  • Pathology
  • Pseudolymphoma

Field of Science

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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